Results 81 to 90 of about 9,786 (244)

Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders [PDF]

, 2016
Non-transferrin-bound iron and its labile (redox active) plasma iron component are thought to be potentially toxic forms of iron originally identified in the serum of patients with iron overload.
Biemond, BJ, Brittenham, GM, Cabantchik, ZI, de Swart, L, Evans, PJ, Furman, Y, GALANELLO, RENZO, Hendriks, JCM, Hider, RC, Hod, EA, Janssen, MCH, Mackenzie, MA, Mattijssen, VEJM, ORIGA, RAFFAELLA, Porter, JB, Swinkels, DW, van der Vorm, LN, Wojczyk, B   +17 more
core   +8 more sources

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

DEFERASIROX: OVER A DECADE OF EXPERIENCE IN THALASSEMIA

Mediterranean Journal of Hematology and Infectious Diseases, 2018
Thalassemia incorporates a broad clinical spectrum characterized by decreased or absent production of normal hemoglobin leading to decreased red blood cell survival and ineffective erythropoiesis. Chronic iron overload remains an inevitable complication resulting from regular blood transfusions (transfusion-dependent) and/or increased iron absorption ...
Rayan Bou-Fakhredin, Nour Moukalled, Ali T. Taher   +2 more
openaire   +5 more sources

Evaluating the theranostic potential of ferumoxytol when combined with radiotherapy in a mammary dual tumor mouse model

Medical Physics, Volume 52, Issue 7, July 2025.
Abstract Background The radiation‐induced abscopal effect (RIAE) is a desirable phenomenon involving radiation‐induced activation of the immune system and regression of metastatic disease after local radiotherapy. However, the majority of patients undergoing radiotherapy do not experience abscopal responses.
Deng‐Yuan Chang, Joseph P. Speth, Matthew L. Scarpelli   +2 more
wiley   +1 more source

Investigating the Effect of Iron Chelation Therapy With Deferasirox on Liver Aminotransferases Levels in Transfusion-dependent β-thalassemia Patients [PDF]

مجله دانشگاه علوم پزشکی گیلان
Background Various body tissues of β-thalassemia patients are exposed to the destructive effects of iron overload due to chronic blood transfusions. Therefore, the decision to start regular blood transfusion therapy for these patients often leads to the ...
Shayan Pourkazem, Mohammadreza Sharifi Rad, Adel Baghersalimi, Soodeh Salehi, Mercedeh Enshaei, Vahid Aminzadeh, Behrang Motamed, Bahram Darbandi   +7 more
doaj  

Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox.

PLoS ONE, 2019
BACKGROUND:Iron overload, resulting from blood transfusions in patients with chronic anemias, has historically been controlled with regular deferoxamine, but its parenteral requirement encouraged studies of orally-active agents, including deferasirox and
Nancy F Olivieri, Amir Sabouhanian, Brenda L Gallie   +2 more
doaj   +1 more source

Efficacy and safety of deferasirox in pediatric patients of thalassemia at a Tertiary Care Teaching Hospital

Indian Journal of Medical and Paediatric Oncology, 2017
Objective: To evaluate efficacy, safety and utilization pattern of deferasirox in paediatric patients of transfusion dependant β Thalassemia Major at a tertiary care teaching hospital in Gujarat.
Dhaval R Thakor, Chetna K Desai, Jigar D Kapadia, Ram K Dikshit, K M Mehariya   +4 more
doaj   +1 more source

Iron chelating agents for iron overload diseases [PDF]

, 2014
Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion.
Crisponi, Guido, Nurchi, Valeria Marina, Zoroddu, Maria Antonietta   +2 more
core   +2 more sources

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

In vitro Studying of Deferasirox Side effects on the Structure and the Function of Bovine Liver Catalase [PDF]

Journal of Fasa University of Medical Sciences, 2014
Background & Objective: Oral chelators such as deferasirox are used to treat iron overload caused by blood transfusion. Considering the significant role of liver in detoxification and drug metabolism as well as the importance of catalase as a key enzyme ...
Maryam Moradi, Adeleh Divsalar, Maryam Saidifar, Ali Akbar Saboury, Mohammad Tahmaseb   +4 more
doaj   +1 more source