Results 81 to 90 of about 13,011 (272)

Peliosis hepatis. Personal experience and literature review [PDF]

, 2015
Peliosis hepatis (PH) is a disease characterized by multiple and small, blood-filled cysts within the parenchymatous organs. PH is a very rare disease, more common in adults, and when it affects the liver, it comes to the surgeon’s attention only in ...
Crocetti, Daniele, D'Orazi, Valerio, Grazi, Gian Luca, Palmieri, Andrea, Pasta, Vittorio, Pedulla', Giuseppe   +5 more
core   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Labile plasma iron levels predict survival in patients with lower-risk Myelodysplastic syndromes [PDF]

, 2017
Red blood cell transfusions remain one of the cornerstones in supportive care of lower-risk patients with myelodysplastic syndromes. We hypothesized that patients develop oxidant mediated tissue injury through the formation of toxic iron species, caused ...
Bagguley, Timothy, Blijlevens, Nicole, Bowen, David, Cermak, Jaroslav, Culligan, Dominic, de Swart, Louise, de Witte, Theo, Droste, Jacqueline, Garelius, Hege, Hellström-Lindberg, Eva, Huls, Gerwin, Krejci, Marta, Langemeijer, Saskia, Macheta, Mac, Panagiotidis, Panagiotis, Reiniers, Chloé, Smith, Alexandra, Spanoudakis, Michail, Swinkels, Dorine W, Symeonidis, Argiris, Tatic, Aurelia, van de Loosdrecht, Arjan A, van Marrewijk, Corine   +22 more
core   +8 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Kidney Tubular Damage Secondary to Deferasirox: Systematic Literature Review

Children, 2021
Deferasirox is a first-line therapy for iron overload that can sometimes cause kidney damage. To better define the pattern of tubular damage, a systematic literature review was conducted on the United States National Library of Medicine, Excerpta Medica,
Martin Scoglio, M. Cappellini, E. D'Angelo, M. Bianchetti, S. Lava, C. Agostoni, G. Milani   +6 more
semanticscholar   +1 more source

Research Progress of Ferroptosis in Cerebral Infarction

Brain and Behavior, Volume 16, Issue 1, January 2026.
Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley   +1 more source

Iron chelating agents for iron overload diseases [PDF]

, 2014
Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion.
Crisponi, Guido, Nurchi, Valeria Marina, Zoroddu, Maria Antonietta   +2 more
core   +2 more sources

Chelation Therapy for Rare Earth Element Toxicity: Current Evidence, Challenges and Future Directions

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up‐to‐date synthesis of current evidence on REE toxicity across multiple exposure pathways, including inhalation, ingestion and occupational contact,
Jose L. Domingo
wiley   +1 more source

Efficacy and safety of deferasirox in pediatric patients of thalassemia at a Tertiary Care Teaching Hospital

Indian Journal of Medical and Paediatric Oncology, 2017
Objective: To evaluate efficacy, safety and utilization pattern of deferasirox in paediatric patients of transfusion dependant β Thalassemia Major at a tertiary care teaching hospital in Gujarat.
Dhaval R Thakor, Chetna K Desai, Jigar D Kapadia, Ram K Dikshit, K M Mehariya   +4 more
doaj   +1 more source

Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan. [PDF]

, 2014
BACKGROUND: There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload.
Dudley J Pennell, E Angelucci, E Angelucci, E Butensky, Gillian Smith, GM Brittenham, GM Brittenham, HG Kreeftenberg, J Porter, J Porter, JB Porter, JB Porter, JC Wood, JC Wood, JC Wood, JM Bland, John B Porter, John-Paul Carpenter, JS Hankins, LJ Anderson, M Barry, M Puliyel, M Ropert-Bouchet, MA Tanner, MA Westwood, Maciej W Garbowski, MB McCarville, MD Cappellini, MD Cappellini, Michael Roughton, MJ Emond, MJ Soriano, Mohammed H Alam, NR Ghugre, P Kirk, PD Jensen, R Fischer, R Origa, RW Chapman, T He, Taigang He, TG St Pierre, TG St Pierre, Y Aydinok, Y Deugnier, Y Feng, Y Gandon   +46 more
core   +1 more source