Results 191 to 200 of about 14,894 (236)

Deferoxamine in Thalassemia Major

New England Journal of Medicine, 1995
N ...
Splendiani G., Tozzo C., Mazzarella V., Casciani C. U., Lucarelli G., Angelucci E., Clift R., Cazzola M., Locatelli F., de Stefano P., Olivieri N. F., Nathan D. G., Cohen A. R.   +12 more
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Deferasirox versus deferoxamine

Blood, 2006
Cappellini and colleagues[1][1] recently published the results of the first large, randomized phase 3 trial comparing deferoxamine (DFO) and deferasirox, a trial designed to demonstrate the efficacy of deferasirox in regularly transfused patients with β-thalassemia.
Michael Gary Martin, Murat O. Arcasoy
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Deferoxamine pharmacokinetics

Seminars in Hematology, 2001
Despite the clinical use of deferoxamine for more than a quarter of a century, pharmacokinetic studies are few and have not been performed explicitly in patients with sickle cell disorders. Early studies with Intravenous administration to healthy volunteers and patients with transfusional overload showed that although peak concentrations of ...
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Role of Deferoxamine in Tumor Therapy

Acta Haematologica, 1996
Several studies are consistent with the hypothesis that available iron may have some role in promoting tumor cell growth with different biological mechanisms. For this reason, several studies have been carried out to demonstrate the antitumor activity of deferoxamine (DFO), an iron chelator with a high affinity for ferritin-bound iron.
Raffaele Cozza, G. Deb, A. Donfrancesco, L. De Sio, Aurora Castellano   +4 more
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Neurotoxicity associated with deferoxamine therapy

Toxicology, 1988
We have documented visual and auditory neurotoxicity in 42 of 89 patients with transfusion-dependent anemia who were receiving iron chelation therapy with subcutaneous deferoxamine (DFO). Of the affected groups, 13 presented with visual loss or deafness or both, and ophthalmologic, audiologic, and visual evoked potential studies (VEPs) uncovered ...
Melvin H. Freedman, Barry Skarf, Margot J. Taylor, Marilyn H. Boyden   +3 more
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Antioxidant properties of deferoxamine

Journal of the American Oil Chemists' Society, 1994
AbstractDeferoxamine, a natural trihydroxamate, was tested for its antioxidant properties. A significant antioxidant effect was detected in linoleic and linolenic acid suspensions, as well as in linoleic acid and fish oil emulsions. Its antioxidant activity was compared to that of butylated hydroxyanisole (BHA) and quercetin.
E. Shimoni, I. Neeman, Robert Armon
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Novel Uses of Deferoxamine

Journal of Pediatric Hematology/Oncology, 1990
Deferoxamine has been extensively used as chelation therapy in iron-overloaded states. Recently, some investigators have explored the potential usefulness of deferoxamine as an antiproliferative, antiinflammatory, and immunosuppressive agent. The studies of deferoxamine have indicated that the drug blocks DNA synthesis by inhibition of ribonucleotide ...
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Treatment of Primary Hemochromatosis With Deferoxamine

JAMA: The Journal of the American Medical Association, 1979
IN PATIENTS with hemochromatosis, congestive heart failure is usually intractable and often heralds rapid deterioration and death. 1 In some cases of primary hemochromatosis, vigorous phlebotomy therapy has resulted in the relief of heart failure and prolonged life.
Walter L. Henry, Arthur W. Nienhuis, Neal S. Young   +2 more
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Solution equilibria of deferoxamine amides

Journal of Pharmaceutical Sciences, 2002
The physico-chemical solution properties of deferoxamine were modified by acylating the terminal amino group with short-chain aliphatic, succinic, and methylsulphonic moieties. The analog iron(III)-binding constants and stabilities under physiological conditions were determined to confirm that the iron binding ability of the parent molecule was ...
Dennis H. Robinson, Peter M. Ihnat, Jonathan L. Vennerstrom   +2 more
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