The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel [PDF]
Nature, 2002 Mechanosensory transduction in touch receptor neurons is believed to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammals.
Miriam B Goodman +2 more
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Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adultC. elegansmuscle [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2016 BACKGROUND: Declines in skeletal muscle structure and function are found in various clinical populations, but the intramuscular proteolytic pathways that govern declines in these individuals remain relatively poorly understood.
Christopher J Gaffney +2 more
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Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit [PDF]
Journal of Biological Chemistry, 2016 Mechanotransduction in Caenorhabditis elegans touch receptor neurons is mediated by an ion channel formed by MEC-4, MEC-10, and accessory proteins. To define the role of these subunits in the channel's response to mechanical force, we expressed degenerin channels comprising MEC-4 and MEC-10 in Xenopus oocytes and examined their response to laminar ...
Shujie Shi, Cliff J Luke, Mark T Miedel
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Neuropeptides and degenerin/epithelial Na+ channels: a relationship from mammals to cnidarians
Journal of Physiology, 2023 Abstract figure legend Several degenerin (DEG)/epithelial Na+ channel (ENaC) ion channels interact with neuropeptides. Some DEG/ENaCs from vertebrates, including humans, are modulated by neuropeptides, whereas others, from bilaterian invertebrates and cnidarians, are directly activated by them. For modulation, neuropeptides [here, RFamides (RFa)] bind,
Stefan Grunder, Gaspar Jékely
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Biochemical Basis of Touch Perception: Mechanosensory Function of Degenerin/Epithelial Na+ Channels [PDF]
Journal of Biological Chemistry, 2002 Michael J Welsh, Margaret P Price
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The synaptic action of Degenerin/Epithelial sodium channels [PDF]
Channels, 2018 Degenerin/Epithelial Sodium Channels (DEG/ENaCs) are a large family of animal-specific non-voltage gated ion channels, with enriched expression in neuronal and epithelial tissues. While neuronal DEG/ENaCs were originally characterized as sensory receptor channels, recent studies indicate that several DEG/ENaC family members are also expressed ...
Alexis S Hill, Yehuda Ben-Shahar
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A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer [PDF]
Cancer Gene Therapy, 2000 Mammalian degenerin (MDEG) is a member of the amiloride-sensitive sodium ion channel family, and its site-directed active mutant (MDEG-G430F) induces massive Na+ influx into cells, leading to cell ballooning and cell bursting. We attempted a novel therapeutic approach for gastric cancers by transferring MDEG-G430F into cancer cells using tumor-specific
Masayoshi Horimoto +2 more
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Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site [PDF]
Journal of Biological Chemistry, 2016 The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin ion channel family, which also includes the bile acid-sensitive ion channel (BASIC). So far little is known about the effects of bile acids on ENaC function. ENaC is probably a heterotrimer consisting of three well characterized subunits (αβγ).
Alexandr V Ilyaskin +2 more
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Abstract: Mechanosensory signaling, believed to be mediated by mechanically gated ion channels, constitutes the basis for the senses of touch and hearing, and contributes fundamentally to the development and homeostasis of all organisms. Despite this profound importance in biology, little is known of the molecular identities or functional requirements
N, Tavernarakis, M, Driscoll
openaire +2 more sources
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans [PDF]
Journal of Biological Chemistry, 1996 Mutations of the degenerins (deg-1, mec-4, mec-10) are the major known causes of hereditary neurodegeneration in the nematode Caenorhabditis elegans. We cloned a neuronal degenerin (MDEG) from human and rat brain. MDEG is an amiloride-sensitive cation channel permeable for Na+, K+, and Li+.
Rainer Waldmann +2 more
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