Results 161 to 170 of about 1,660 (170)

A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans

American Journal of Physiology-Cell Physiology, 2004
In Caenorhabditis elegans, the gene unc-1 controls anesthetic sensitivity and normal locomotion. The protein UNC-1 is a close homolog of the mammalian protein stomatin and is expressed primarily in the nervous system. Genetic studies in C. elegans have shown that the UNC-1 protein interacts with a sodium channel subunit, UNC-8.
M M, Sedensky, J M, Siefker, J Y, Koh, D M, Miller, P G, Morgan   +4 more
openaire   +2 more sources

Modularity in the ENaC/Degenerin Family Facilitates Transfer of Functional Properties Between Family Members

The FASEB Journal, 2017
Members of the epithelial Na + channel (ENaC)/Degenerin family are cation selective channels that respond to the extracellular environment. ENaCs and acid sensing ion channels (ASICs) are found in all tetrapods and are involved in diverse processes ranging from renal Na +
Michael A DeMarco, Xue‐Ping Wang, Deidra M Balchak, Koehler Powell, Anindit Mukherjee, Brandon M Blobner, Ossama B Kashlan   +6 more
openaire   +1 more source

Caenorhabditis ElegansDegenerins and Vertebrate Enac Ion Channels Contain an Extracellular Domain Related to Venom Neurotoxins

Journal of Neurogenetics, 2000
The DEG/ENaC (DEGenerin/Epithelial Na+ Channel) superfamily includes closely related ion channel subunits from divergent species ranging from the simple nematode Caenorhabditis elegans to humans. Members of this protein group play roles in several important processes including transduction of mechanical stimuli, sodium re-absorption and blood pressure ...
N, Tavernarakis, M, Driscoll
openaire   +2 more sources

Computational and Experimental Exploration of Ion Selectivity in the Epithelial Sodium Channel/Degenerin (ENaC/DEG) Family

Ion channels are pore-forming proteins that allow the diffusion of charged particles through the plasma membrane. They play an important role in many cellular functions and are also vital drug targets. One key characteristic to their proper function is their ion selectivity, yet, the mechanisms underlying this are still not fully understood.
openaire   +2 more sources

The Genetic Architecture of Degenerin/Epithelial Sodium Channels inDrosophila

G3: Genes, Genomes, Genetics, 2013
Sarah C Pyfrom, Yehuda Ben-Shahar
exaly  

ENAC, Degenerins, ASICs, and Related Channels

2013
openaire   +1 more source

The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids

Pflugers Archiv European Journal of Physiology, 2018
Alexandr V Ilyaskin, Rainer A Böckmann, Heinrich Sticht   +2 more
exaly  

Epithelial Sodium Channel (ENAC)/Degenerin (DEG) Superfamily of Ion Channels

Bruce A Stanton, Dale J Benos
exaly  

ASIC2a: Mammalian Degenerin 1 (MDEG1), Brain Sodium Channel 1 (BNC1a, BNaC1a)

2013
openaire   +1 more source

Degenerin

exaly