Results 71 to 80 of about 22,703 (264)

Effect of a bacterial inoculum and additive on dry matter in situ degradability of sugarcane silage

Journal of Integrative Agriculture, 2015
The objective of this study was to evaluate the effect of adding a bacterial inoculum and a handmade additive to sugarcane silage (SCS) on the in situ digestibility of dry matter (DM).
José A Reyes-Gutiérrez, Oziel D Montañez-Valdez, Ramón Rodríguez-Macias, Mario Ruíz-López, Eduardo Salcedo-Pérez, Cándido E Guerra-Medina   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Advances in Formulations of Microneedle System for Rheumatoid Arthritis Treatment

International Journal of Nanomedicine, 2023
Peng Guo,1,* Chi Huang,2,* Qin Yang,1 Guofeng Zhong,1 Junbo Zhang,1 Mengyu Qiu,1 Rui Zeng,3 Kaijun Gou,3 Chen Zhang,1 Yan Qu1 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional ...
Guo P, Huang C, Yang Q, Zhong G, Zhang J, Qiu M, Zeng R, Gou K, Zhang C, Qu Y   +9 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Valor nutritivo do colmo de híbridos de milho colhidos em três estádios de maturidade Stalk nutritive value of corn hybrids harvested at three maturity stages

Pesquisa Agropecuária Brasileira, 2010
O objetivo deste trabalho foi avaliar o efeito da maturidade da planta sobre a qualidade nutricional do colmo de híbridos de milho, para definir critérios de seleção em programas de melhoramento de milho para ensilagem.
Diego Reynaga Salazar, Samuel dos Santos Stabile, Paula de Souza Guimarães, Maria Elisa Ayres Guidetti Zagatto Paterniani, Marcos Veiga dos Santos, Luis Felipe Prada e Silva   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Predicting Drug Release From Degradable Hydrogels Using Fluorescence Correlation Spectroscopy and Mathematical Modeling

Frontiers in Bioengineering and Biotechnology, 2019
Predicting release from degradable hydrogels is challenging but highly valuable in a multitude of applications such as drug delivery and tissue engineering.
Saahil Sheth, Emily Barnard, Ben Hyatt, Muruhan Rathinam, Silviya Petrova Zustiak   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Nitrogen degradability and intestinal digestibility of rumen undegraded protein in rapeseed, rapeseed meal and extracted rapeseed meal

Czech Journal of Animal Science, 2007
In this study, nutritive values of rapeseed (R), rapeseed meal-expeller A (RM-A), rapeseed meal-expeller B (RM-B) and extracted rapeseed meal (ERM) were compared.
P. Homolka, J. Harazim, J. Třináctý
doaj   +1 more source