Results 71 to 80 of about 2,784 (175)

A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact.

PLoS Pathogens, 2019
Numerous Gram-negative pathogens use a Type III Secretion System (T3SS) to promote virulence by injecting effector proteins into targeted host cells, which subvert host cell processes.
Maria Kusmierek, Jörn Hoßmann, Rebekka Witte, Wiebke Opitz, Ines Vollmer, Marcel Volk, Ann Kathrin Heroven, Hans Wolf-Watz, Petra Dersch   +8 more
doaj   +1 more source

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure

Molecular Microbiology, Volume 123, Issue 3, Page 279-293, March 2025.
Polyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome‐depleted nucleoid region of bacterial cells, particularly under stress (in this case Pseudomonas aeruginosa undergoing nitrogen starvation; adapted with permission from (Racki et al. 2017)). This Perspective explores the emerging view
Lisa R. Racki, Lydia Freddolino
wiley   +1 more source

Effects of lipid membranes on RNA catalytic activity and stability

Biology of the Cell, Volume 117, Issue 2, February 2025.
This study explores how lipid membranes influence the activity and stability of natural ribozymes. We found that lipid membranes can both decrease and enhance ribozyme activity. We also observed that lipid membranes promote RNA degradation, depending on lipid composition and membrane fluidity.
Tomasz Czerniak, James P. Saenz
wiley   +1 more source

Flotillins in membrane trafficking and physiopathology

Biology of the Cell, Volume 117, Issue 1, January 2025.
Flotillin 1 and 2 scaffold sphingolipid‐rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1‐phosphate (S1P) by sphingosine kinase 2 (SphK2). Hence they deregulate protein cargo trafficking and influence cell signaling and cellular invasion.
Stéphane Bodin, Hadeer Elhabashy, Ewan Macdonald, Dominic Winter, Cécile Gauthier‐Rouvière   +4 more
wiley   +1 more source

The contribution of mRNA targeting to spatial protein localization in bacteria

The FEBS Journal, Volume 291, Issue 21, Page 4639-4659, November 2024.
mRNA‐based targeting serves as a back‐up strategy for the canonical signal sequence‐based protein targeting in bacteria. While signal sequence‐based targeting depends on dedicated protein‐targeting factors, mRNAs encoding inner membrane proteins can bind directly to protein translocases.
Wenkang Shang, Elisabeth Lichtenberg, Andreea Mihaela Mlesnita, Annegret Wilde, Hans‐Georg Koch   +4 more
wiley   +1 more source

Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome [PDF]

Nucleic Acids Research, 2014
The endoribonuclease RNase E is a key enzyme in RNA metabolism for many bacterial species. In Escherichia coli, RNase E contributes to the majority of RNA turnover and processing events, and the enzyme has been extensively characterized as the central component of the RNA degradosome assembly.
Voss, Jarrod E, Luisi, Ben F, Hardwick, Steven W   +2 more
openaire   +3 more sources

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis in Staphylococcus aureus.

PLoS Genetics, 2020
Staphylococcus aureus is an opportunistic pathogen that can grow in a wide array of conditions: on abiotic surfaces, on the skin, in the nose, in planktonic or biofilm forms and can cause many type of infections. Consequently, S.
Vanessa Khemici, Julien Prados, Bianca Petrignani, Benjamin Di Nolfi, Elodie Bergé, Caroline Manzano, Caroline Giraud, Patrick Linder   +7 more
doaj   +1 more source

Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter‐to‐Life Transitions

ChemSystemsChem, Volume 6, Issue 4, July 2024.
This review examines discoveries of biomolecular condensates as compartments in bacteria. Insights from bacterial cell biology and systems chemistry reveal intricate connections between chemical reactions and the control of condensate phase separation.
Wade E. Schnorr, W. Seth Childers
wiley   +1 more source

Pseudomonas aeruginosa enolase influences bacterial tolerance to oxidative stresses and virulence

Frontiers in Microbiology, 2016
Pseudomonas aeruginosa is a Gram negative opportunistic pathogenic bacterium, which causes acute and chronic infections. Upon entering host, bacteria alter global gene expression to adapt to host environment and avoid clearance by host.
Yuding Weng, Fei Chen, Yiwei Liu, Qiang Zhao, Xiaolei Pan, Chang Liu, Ronghao Chen, Zhihui Cheng, Shouguang Jin, Shouguang Jin, Yongxin Jin, Weihui Wu   +11 more
doaj   +1 more source

Escherichia coli strains with precise domain deletions in the ribonuclease RNase E can achieve greatly enhanced levels of membrane protein production

Protein Science, Volume 33, Issue 2, February 2024.
Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou, Tania Chroumpi, Georgios Skretas   +2 more
wiley   +1 more source