Results 81 to 90 of about 4,051 (196)

A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact.

PLoS Pathogens, 2019
Numerous Gram-negative pathogens use a Type III Secretion System (T3SS) to promote virulence by injecting effector proteins into targeted host cells, which subvert host cell processes.
Maria Kusmierek, Jörn Hoßmann, Rebekka Witte, Wiebke Opitz, Ines Vollmer, Marcel Volk, Ann Kathrin Heroven, Hans Wolf-Watz, Petra Dersch   +8 more
doaj   +1 more source

CRP-cAMP mediates silencing of Salmonella virulence at the post-transcriptional level [PDF]

, 2018
Invasion of epithelial cells by Salmonella enterica requires expression of genes located in the pathogenicity island I (SPI-1). The expression of SPI-1 genes is very tightly regulated and activated only under specific conditions.
Balsalobre, Carlos, El Mouali, Youssef, Gaviria-Cantin, Tania, Gilbert, Marta, Sánchez Romero, María Antonia, Vogel, Jörg, Westermann, Alexander J.   +6 more
core   +4 more sources

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

The Power Duo: How the Interplay Between Nucleoid‐Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony

Molecular Microbiology, Volume 123, Issue 6, Page 531-546, June 2025.
Nucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Sara Moutacharrif, Feth El Zahar Haichar, Sam Meyer, Cecile Ribot, Sylvie Reverchon, William Nasser, Florence Hommais   +6 more
wiley   +1 more source

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure

Molecular Microbiology, Volume 123, Issue 3, Page 279-293, March 2025.
Polyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome‐depleted nucleoid region of bacterial cells, particularly under stress (in this case Pseudomonas aeruginosa undergoing nitrogen starvation; adapted with permission from (Racki et al. 2017)). This Perspective explores the emerging view
Lisa R. Racki, Lydia Freddolino
wiley   +1 more source

Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome [PDF]

Genes & Development, 1998
The Escherichia coli RNA degradosome is the prototype of a recently discovered family of multiprotein machines involved in the processing and degradation of RNA. The interactions between the various protein components of the RNA degradosome were investigated by Far Western blotting, the yeast two-hybrid assay, and coimmunopurification experiments.
N F, Vanzo, Y S, Li, B, Py, E, Blum, C F, Higgins, L C, Raynal, H M, Krisch, A J, Carpousis   +7 more
openaire   +2 more sources

Effects of lipid membranes on RNA catalytic activity and stability

Biology of the Cell, Volume 117, Issue 2, February 2025.
This study explores how lipid membranes influence the activity and stability of natural ribozymes. We found that lipid membranes can both decrease and enhance ribozyme activity. We also observed that lipid membranes promote RNA degradation, depending on lipid composition and membrane fluidity.
Tomasz Czerniak, James P. Saenz
wiley   +1 more source

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]

, 2009
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo, Beech, Bernardi, Bernardi, Borden, Bourhis, Callaghan, Carvalho, Condemine, Condemine, Dalessio, Doucas, E. Emmott, Evans, Everett, Everett, Everett, Fagioli, Fagioli, Hoppe, Ishov, Janderova-Rossmeislova, Jensen, K. N. Leppard, Kalderon, Kelly, Liu, M. S. Cortese, Mohan, Nevels, Peng, Romero, Salomoni, Scaglioni, Shen, Sternsdorf, Stracker, T. Rich   +37 more
core   +1 more source

Flotillins in membrane trafficking and physiopathology

Biology of the Cell, Volume 117, Issue 1, January 2025.
Flotillin 1 and 2 scaffold sphingolipid‐rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1‐phosphate (S1P) by sphingosine kinase 2 (SphK2). Hence they deregulate protein cargo trafficking and influence cell signaling and cellular invasion.
Stéphane Bodin, Hadeer Elhabashy, Ewan Macdonald, Dominic Winter, Cécile Gauthier‐Rouvière   +4 more
wiley   +1 more source

The role of ribonucleases in regulating global mRNA levels in the model organism Thermus thermophilus HB8 [PDF]

, 2014
BACKGROUND: RNA metabolism, including RNA synthesis and RNA degradation, is one of the most conserved biological systems and has been intensively studied; however, the degradation network of ribonucleases (RNases) and RNA substrates is not fully ...
Akeo Shinkai, Hiromasa Ohyama, Kenji Fukui, Noriko Nakagawa, Ryoji Masui, Seiki Kuramitsu, Tomofumi Sakai, Yoshihiro Agari   +7 more
core   +1 more source