Results 1 to 10 of about 3,502 (177)

Membrane recognition and dynamics of the RNA degradosome. [PDF]

PLoS Genetics, 2015
RNase E, which is the central component of the multienzyme RNA degradosome, serves as a scaffold for interaction with other enzymes involved in mRNA degradation including the DEAD-box RNA helicase RhlB.
Henrik Strahl, Catherine Turlan, Syma Khalid, Peter J Bond, Jean-Marie Kebalo, Pascale Peyron, Leonora Poljak, Marie Bouvier, Leendert Hamoen, Ben F Luisi, Agamemnon J Carpousis   +10 more
doaj   +7 more sources

The social fabric of the RNA degradosome. [PDF]

Biochim Biophys Acta, 2013
Bacterial transcripts each have a characteristic half-life, suggesting that the processes of RNA degradation work in an active and selective manner. Moreover, the processes are well controlled, thereby ensuring that degradation is orderly and coordinated.
Bandyra KJ, Bouvier M, Carpousis AJ, Luisi BF.   +3 more
europepmc   +5 more sources

The RNase J-Based RNA Degradosome Is Compartmentalized in the Gastric Pathogen Helicobacter pylori [PDF]

mBio, 2020
Posttranscriptional regulation is a major level of gene expression control in any cell. In bacteria, multiprotein machines called RNA degradosomes are central for RNA processing and degradation, and some were reported to be compartmentalized inside these
Alejandro Tejada-Arranz, Eloïse Galtier, Lamya El Mortaji, Evelyne Turlin, Dmitry Ershov, Hilde De Reuse   +5 more
doaj   +5 more sources

Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates. [PDF]

PLoS Biology, 2023
RNA processing and degradation shape the transcriptome by generating stable molecules that are necessary for translation (rRNA and tRNA) and by facilitating the turnover of mRNA, which is necessary for the posttranscriptional control of gene expression ...
Lydia Hadjeras, Marie Bouvier, Isabelle Canal, Leonora Poljak, Quentin Morin-Ogier, Carine Froment, Odile Burlet-Schlitz, Lina Hamouche, Laurence Girbal, Muriel Cocaign-Bousquet, Agamemnon J Carpousis   +10 more
doaj   +2 more sources

Multi-scale ensemble properties of the Escherichia coli RNA degradosome. [PDF]

Mol Microbiol, 2022
AbstractIn organisms from all domains of life, multi‐enzyme assemblies play central roles in defining transcript lifetimes and facilitating RNA‐mediated regulation of gene expression. An assembly dedicated to such roles, known as the RNA degradosome, is found amongst bacteria from highly diverse lineages.
Dendooven T, Paris G, Shkumatov AV, Islam MS, Burt A, Kubańska MA, Yang TY, Hardwick SW, Luisi BF.   +8 more
europepmc   +6 more sources

Localization of components of the RNA-degrading machine in Bacillus subtilis [PDF]

Frontiers in Microbiology, 2016
In bacteria, the control of mRNA stability is crucial to allow rapid adaptation to changing conditions. In most bacteria, RNA degradation is catalyzed by the RNA degradosome, a protein complex composed of endo- and exoribonucleases, RNA helicases and ...
Nora Cascante-Estepa, Katrin Gunka, Jörg Stülke   +2 more
doaj   +6 more sources

Cooperation of regulatory RNA and the RNA degradosome in transcript surveillance. [PDF]

Nucleic Acids Res
Abstract The ompD transcript, encoding an outer membrane porin in Salmonella, harbors a controlling element in its coding region that base-pairs imperfectly with a ‘seed’ region of the small regulatory RNA (sRNA) MicC. When tagged with the sRNA, the ompD mRNA is cleaved downstream of the pairing site by the conserved endoribonuclease ...
Bandyra KJ, Fröhlich KS, Vogel J, Rodnina M, Goyal A, Luisi BF.   +5 more
europepmc   +9 more sources

Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay. [PDF]

Protein Sci, 2022
AbstractHuman Suv3 is a unique homodimeric helicase that constitutes the major component of the mitochondrial degradosome to work cooperatively with exoribonuclease PNPase for efficient RNA decay. However, the molecular mechanism of how Suv3 is assembled into a homodimer to unwind RNA remains elusive.
Jain M, Golzarroshan B, Lin CL, Agrawal S, Tang WH, Wu CJ, Yuan HS.   +6 more
europepmc   +3 more sources

Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components [PDF]

Nature Communications, 2018
The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3.
Michal Razew, Zbigniew Warkocki, Michal Taube, Adam Kolondra, Mariusz Czarnocki-Cieciura, Elzbieta Nowak, Karolina Labedzka-Dmoch, Aleksandra Kawinska, Jakub Piatkowski, Pawel Golik, Maciej Kozak, Andrzej Dziembowski, Marcin Nowotny   +12 more
doaj   +2 more sources

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome [PDF]

eLife, 2016
In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is an important mechanism to prevent host infection.
An Van den Bossche, Steven W Hardwick, Pieter-Jan Ceyssens, Hanne Hendrix, Marleen Voet, Tom Dendooven, Katarzyna J Bandyra, Marc De Maeyer, Abram Aertsen, Jean-Paul Noben, Ben F Luisi, Rob Lavigne   +11 more
doaj   +2 more sources