Nature Communications, 2023 Ribonucleases (RNases) are responsible for RNA metabolism. RNase J, the core enzyme of the RNA degradosome, plays an essential role in global mRNA decay.
Luyao Bao +15 more
doaj +1 more source
The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions
Cell Reports, 2023 Summary: Bacterial ribonucleoprotein bodies (BR-bodies) are non-membrane-bound structures that facilitate mRNA decay by concentrating mRNA substrates with RNase E and the associated RNA degradosome machinery.
Vidhyadhar Nandana +16 more
doaj +1 more source
LEVELNET to visualize, explore, and compare protein–protein interaction networks
PROTEOMICS, Volume 23, Issue 17, September 2023., 2023 Abstract Physical interactions between proteins are central to all biological processes. Yet, the current knowledge of who interacts with whom in the cell and in what manner relies on partial, noisy, and highly heterogeneous data. Thus, there is a need for methods comprehensively describing and organizing such data.
Yasser Mohseni Behbahani +4 more
wiley +1 more source
Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA
Frontiers in Molecular Biosciences, 2023 The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche +2 more
doaj +1 more source
Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus [PDF]
, 2019 Interferon response suppression by the respiratory syncytial virus relies on two unique nonstructural proteins, NS1 and NS2, that interact with cellular partners through high-order complexes.
Alonso, Leonardo Gabriel +9 more
core +1 more source
Caught in the act—Visualizing ribonucleases during eukaryotic ribosome assembly
WIREs RNA, Volume 14, Issue 4, July/August 2023., 2023 Ribonucleolytic processing of precursor ribosomal RNAs is an essential aspect of ribosome production. Structural snapshots of pre‐ribosomal particles provide new insights into how ribonuclease activities are regulated spatially and temporally during ribosome assembly.
Claudia Schneider, Katherine E. Bohnsack
wiley +1 more source
Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry [PDF]
, 2014 The RNase E family is renowned for being central to the processing and decay of all types of RNA in many species of bacteria, as well as providing the first examples of endonucleases that can recognize 50 -monophosphorylated ends thereby increasing
Andrade +67 more
core +2 more sources
mSystems, 2023 Both prokaryotic and eukaryotic RNAs can be 5′-capped by the metabolite nicotinamide adenine dinucleotide (NAD). Nudix hydrolases, such as bacterial NudC, specifically remove NAD-caps; however, the molecular and cellular functions of these ...
Milda Mickutė +10 more
doaj +1 more source
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
, 2012 Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor +58 more
core +1 more source
SR7 – a dual-function antisense RNA from Bacillus subtilis
RNA Biology, 2021 Here, we describe SR7, a dual-function antisense RNA encoded on the Bacillus subtilis chromosome. This RNA was earlier described as SigB-dependent regulatory RNA S1136 and reported to reduce the amount of the small ribosomal subunit under ethanol stress.
Inam Ul Haq +2 more
doaj +1 more source