Results 61 to 70 of about 738,204 (145)

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You   +3 more
wiley   +1 more source

Cyanobacterial RNA Helicase CrhR Localizes to the Thylakoid Membrane Region and Cosediments with Degradosome and Polysome Complexes in Synechocystis sptrain PCC 6803

, 2016
The cyanobacterium Synechocystis sp. strain PCC 6803 encodes a single DEAD box RNA helicase, CrhR, whose expression is tightly autoregulated in response to cold stress.
Whitford, Denise S., Owttrim, George W., Fahlman, Richard P., Rosana, Albert R. R.   +3 more
core   +1 more source

Studies of the RNA Degradosome-organizing Domain of the Escherichia coli Ribonuclease RNase E. [PDF]

, 2004
The hydrolytic endoribonuclease RNase E, which is widely distributed in bacteria and plants, plays key roles in mRNA degradation and RNA processing in Escherichia coli.
Ilag, LL, Kuhnel K, Aurikko, J., Callaghan, AJ, Symmons, MF, Callaghan AJ, Symmons M, Symmons, M., Luisi, B., Robinson, CV, Carpousis, A., Robinson, Carol V., Aurikko J, Gunter Grossmann, J., Poljak, L, Ilag, L., Ilag L, Luisi B, Aurikko, JP, Kühnel, K, Luisi, BF, Poljak, L., Illag, L., Carpousis A, Grossmann G, Poljak L, Carpousis, AJ, Callaghan, Anastasia, Chandran, V, Günter Grossmann, J, Grossmann, G., Robinson C, Callaghan, A., Kuhnel, K., Chandran V, Chandran, V., Robinson, C.   +36 more
core   +1 more source

The ribonuclease E regulator RebA is essential for diazotrophic growth in the cyanobacterium Anabaena PCC 7120

mLife, Volume 4, Issue 5, Page 516-526, October 2025.
Abstract Ribonuclease E (RNase E) is central to bacterial RNA metabolism. In cyanobacteria, its activity is inhibited by RebA, a key mechanism for controlling cell morphology. Here, we demonstrate that rebA is essential for diazotrophic growth of Anabaena PCC 7120, a filamentous cyanobacterium capable of forming heterocysts—specialized nitrogen‐fixing ...
Sujuan Liu, Zhenyu Wang, Guiming Lin, Wenkai Li, Xiaoli Zeng, Ju‐Yuan Zhang, Cheng‐Cai Zhang   +6 more
wiley   +1 more source

From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome

, 2011
The RNA degradosome is a massive multi-enzyme assembly that occupies a nexus in RNA metabolism and post-transcriptional control of gene expression inEscherichia coliand many other bacteria.
Agamemnon J. Carpousis, Maria W. Górna, Ben F. Luisi   +2 more
core   +1 more source

Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome

MedComm, Volume 6, Issue 9, September 2025.
In quiescent PECs, Eno1 binds to the 3′ UTR of CXCL12 mRNA to prevent translation. Following activation, lactate is accumulated and then mediates an increase in lysine lactylation. Eno1, a substrate in this modification, releases bound CXCL12 mRNA upon lactylation to promote translation. Meanwhile, the activity of Eno1 as a glycolytic enzyme increases,
Xu Liu, Haofei Wang, Weijie Ni, Xuecheng Dong, Mingzhu Zheng, Wei Chang   +5 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

The Power Duo: How the Interplay Between Nucleoid‐Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony

Molecular Microbiology, Volume 123, Issue 6, Page 531-546, June 2025.
Nucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Sara Moutacharrif, Feth El Zahar Haichar, Sam Meyer, Cecile Ribot, Sylvie Reverchon, William Nasser, Florence Hommais   +6 more
wiley   +1 more source

The RNA processing enzyme polynucleotide phosphorylase negatively controls biofilm formation by repressing poly-N-acetylglucosamine (PNAG) production in Escherichia coli C

BMC Microbiology, 2012
Background Transition from planktonic cells to biofilm is mediated by production of adhesion factors, such as extracellular polysaccharides (EPS), and modulated by complex regulatory networks that, in addition to controlling production of adhesion ...
Carzaniga Thomas, Antoniani Davide, Dehò Gianni, Briani Federica, Landini Paolo   +4 more
doaj   +1 more source

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure

Molecular Microbiology, Volume 123, Issue 3, Page 279-293, March 2025.
Polyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome‐depleted nucleoid region of bacterial cells, particularly under stress (in this case Pseudomonas aeruginosa undergoing nitrogen starvation; adapted with permission from (Racki et al. 2017)). This Perspective explores the emerging view
Lisa R. Racki, Lydia Freddolino
wiley   +1 more source