Results 71 to 80 of about 738,204 (145)
Effects of lipid membranes on RNA catalytic activity and stability
Biology of the Cell, Volume 117, Issue 2, February 2025.This study explores how lipid membranes influence the activity and stability of natural ribozymes. We found that lipid membranes can both decrease and enhance ribozyme activity. We also observed that lipid membranes promote RNA degradation, depending on lipid composition and membrane fluidity.
Tomasz Czerniak, James P. Saenz
wiley +1 more source
The contribution of mRNA targeting to spatial protein localization in bacteria
The FEBS Journal, Volume 291, Issue 21, Page 4639-4659, November 2024.mRNA‐based targeting serves as a back‐up strategy for the canonical signal sequence‐based protein targeting in bacteria. While signal sequence‐based targeting depends on dedicated protein‐targeting factors, mRNAs encoding inner membrane proteins can bind directly to protein translocases.
Wenkang Shang +4 more
wiley +1 more source
A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity
eLife, 2019 CRISPR-Cas systems provide sequence-specific immunity against phages and mobile genetic elements using CRISPR-associated nucleases guided by short CRISPR RNAs (crRNAs).
Lucy Chou-Zheng, Asma Hatoum-Aslan
doaj +1 more source
ChemSystemsChem, Volume 6, Issue 4, July 2024.This review examines discoveries of biomolecular condensates as compartments in bacteria. Insights from bacterial cell biology and systems chemistry reveal intricate connections between chemical reactions and the control of condensate phase separation.
Wade E. Schnorr, W. Seth Childers
wiley +1 more source
Protein Science, Volume 33, Issue 2, February 2024.Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou +2 more
wiley +1 more source
, 2010 P>In most organisms, dedicated multiprotein complexes, called exosome or RNA degradosome, carry out RNA degradation and processing. In addition to varying exoribonucleases or endoribonucleases, most of these complexes contain a RNA helicase.
Henrike Pförtner +11 more
core +1 more source
Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]
, 2012 tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena +3 more
core +1 more source
Formation of a membraneless compartment regulates bacterial virulence
Nature CommunicationsThe RNA-binding protein CsrA regulates the expression of hundreds of genes in several bacterial species, thus controlling virulence and other processes.
Lior Aroeti +11 more
doaj +1 more source
Pseudomonas aeruginosa enolase influences bacterial tolerance to oxidative stresses and virulence
Frontiers in Microbiology, 2016 Pseudomonas aeruginosa is a Gram negative opportunistic pathogenic bacterium, which causes acute and chronic infections. Upon entering host, bacteria alter global gene expression to adapt to host environment and avoid clearance by host.
Yuding Weng +11 more
doaj +1 more source
Recent insights into the world of dual‐function bacterial sRNAs
WIREs RNA, Volume 15, Issue 1, January/February 2024.Dual‐function sRNAs are fascinating riboregulators that act both as base‐pairing antisense RNAs and as peptide‐coding mRNAs, offering the possibility to control target function at different regulatory levels via RNA–RNA interactions as well as protein–protein interactions.
Sebastian Benjamin Schnoor +2 more
wiley +1 more source