Results 181 to 190 of about 63,047 (307)

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27. [PDF]

Arthritis Res Ther
Tang K, Ma X, Gao J, Zu L, Ma Y, Zhuo D, Wu C, Tang Y, Qian F, Jin L, Wang J, Zhu Q, Liu J.   +12 more
europepmc   +1 more source

284 Neutrophil induced mast cell degranulation

, 1985
Martha V. White, Michael Kaliner
openalex   +1 more source

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Immune checkpoints in tumor immunotherapy. Ligand binding to the receptor inhibits immune cell function, promotes tumor cell immune escape, and suppresses the immune response. The pathways of action are VISTA‐IGSF11, TIM‐3‐Ceacam1, CD47‐SIRPα, CTLA‐4‐CD80/CD86, PD‐L1‐PD‐1, MHC‐1‐LILRB, and CD24 ‐ Siglec ‐10. There are also other immune checkpoints such
Han Sun, Dan Huang, Huiling Zhang, Mingyuan Dong, Simiao Wang, Man Sun, Jiayi Liu, Yiqi Wang, Xiaojie Qu, Xuefeng Li, Zhaogang Yang   +10 more
wiley   +1 more source

Radiation Dermatitis: A Comparative Review of Prevention and Management

Dermatological Reviews, Volume 6, Issue 4, August 2025.
ABSTRACT Background Radiation dermatitis (RD) is a universal side effect of radiation therapy (RT), with management strategies differing depending on the type of cancer being treated. This review highlights the pathogenesis and management of RD following treatment of internal malignancies versus non‐melanoma skin cancers (NMSC) treated with superficial
Aysham Chaudry, Robert J. Vanaria, Mark S. Nestor   +2 more
wiley   +1 more source

The yield of Limulus amoebocyte lysate (LAL), which is used for endotoxin detection and adjunct diagnosis of invasive fungal infection, was optimized with caffeine collection buffer. [PDF]

Front Microbiol
Zhang S, Zhang M, Zhang J.
europepmc   +1 more source

Bleeding Complications in JAK2‐Variant Essential Thrombocythemia: A Revisit in 2025

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterised by sustained thrombocytosis. Paradoxically, bleeding complications remain an under‐recognised clinical challenge. Compared with CALR‐mutated patients, those harbouring the JAK2‐V617F variant appear more prone to haemorrhage.
Gerard Gurumurthy, Samantha Gurumurthy, Tim C. P. Somervaille, Anna Falanga, Jecko Thachil   +4 more
wiley   +1 more source

47 Calcium dependent ionophore A23187 induced eosinophil degranulation and cytolysis

, 1985
Takabumi FUKUDA, Steven J. Ackerman, C REED, M PETERS, Sandra L. Dunnette, G GLEICH   +5 more
openalex   +1 more source

Cannabinoids and the Endocannabinoid System in the Treatment of Chronic Rhinosinusitis

The Laryngoscope, Volume 135, Issue 8, Page 2683-2690, August 2025.
The objective of this scoping review is to explore the role of the ECS in the pathophysiology of CRS. We identified five studies, all supporting a common conclusion that the ECS is implicated in regulating cellular inflammatory pathways potentially involved in sinonasal disease.
John J. W. Lee, Amr F. Hamour, Jacob G. J. Wihlidal, John M. Lee, Eric Monteiro, Ewa Poduch, Lakshmi Kotra, Allan D. Vescan   +7 more
wiley   +1 more source

Transcriptional signature of rapidly responding NK cells reveals S1P5 and CXCR4 as anti-tumor response disruptors. [PDF]

Sci Rep
Puig-Gámez M, Van Attekum M, Theis T, Dick A, Park JE.   +4 more
europepmc   +1 more source