Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored. METHODS We conducted a comprehensive analysis of RNA editing across nine human brain regions affected by AD, utilizing RNA‐seq data and matched whole‐genome sequencing data ...
Amit Kumar Gupta +5 more
wiley +1 more source
Is there a role of genetics in acute and chronic urticaria—A systematic review and meta‐analysis
Clinical and Translational Allergy, Volume 15, Issue 7, July 2025.Abstract Background Chronic urticaria (CU) is a heterogeneous skin disorder whose genetic drivers are incompletely defined. Objective To systematically review and meta‐analyse genetic and epigenetic factors that influence susceptibility and treatment response in acute and CU.
George N. Konstantinou +2 more
wiley +1 more source
Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial. [PDF]
Front NutrPiccolo V +5 more
europepmc +1 more source
Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways
Clinical and Translational Allergy, Volume 15, Issue 7, July 2025.ABSTRACT Background Eotaxins (EOTs), primarily expressed in airway epithelial cells (AECs), act as chemoattractants for eosinophils in asthma pathogenesis. Recent studies have suggested that EOTs have additional functions beyond chemotaxis. However, the distinct roles of EOTs remain incompletely understood.
Soyoon Sim +5 more
wiley +1 more source
Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. [PDF]
Signal Transduct Target TherAl Hamwi G +24 more
europepmc +1 more source
CD70: An emerging target for integrated cancer diagnosis and therapy
Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.CD70 is aberrantly overexpressed in diverse tumours with limited normal tissue expression, making it a compelling diagnostic and therapeutic target. Immuno‐PET/CT facilitates tumour detection, staging, and treatment monitoring. Multiple CD70‐targeted therapies are under early evaluation. Rational combination strategies are emerging to enhance antitumor
Jiatao Hu +9 more
wiley +1 more source
Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence. [PDF]
J Clin InvestLiegeois MA +6 more
europepmc +1 more source
Microfilament-associated degranulation from rat peritoneal mast cells
, 1990 Masaaki Akagi +2 more
openalex +1 more source
nuTCRacker: Predicting the Recognition of HLA‐I–Peptide Complexes by αβTCRs for Unseen Peptides
European Journal of Immunology, Volume 55, Issue 7, July 2025.nuTCRacker aims to predict unseen αβTCR‐peptide‐HLA‐I affinity. Predictions are successful for only a subset of unseen peptides although they are better than the benchmarked methods. Predictions are tested on both novel and published T cell assays. ABSTRACT The ability to predict which antigenic peptide(s) the αβTCR of a given CD8+ T‐cell clone can ...
Justin Barton +4 more
wiley +1 more source
FGA can be used as a promising therapeutic target in osteoarthritis. [PDF]
BMC Musculoskelet DisordChen G, Zhang H, Bai X.
europepmc +1 more source