Results 61 to 70 of about 137,298 (386)
Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation
Journal of Innate Immunity, 2021 Mast cells (MCs) are key mediators of allergic inflammation through the activation of cross-linked immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcϵRI) on the cell surface, leading to the release of biologically potent mediators, either
Edwin Leong +3 more
doaj +1 more source
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
, 2012 BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L +8 more
core +2 more sources
Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches
Cells, 2023 Mast cells (MCs) are the immune cells distributed throughout nearly all tissues, mainly in the skin, near blood vessels and lymph vessels, nerves, lungs, and the intestines.
Joanna Baran +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]
, 2010 Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L +2 more
core +3 more sources
Hypoxia upregulates neutrophil degranulation and potential for tissue injury
Thorax, 2016 Background The inflamed bronchial mucosal surface is a profoundly hypoxic environment. Neutrophilic airway inflammation and neutrophil-derived proteases have been linked to disease progression in conditions such as COPD and cystic fibrosis, but the ...
K. Hoenderdos +12 more
semanticscholar +1 more source
Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source
Frontiers in Allergy, 2022 As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang +12 more
doaj +1 more source
Insights on cytotoxic cells of the colonial ascidian Botryllus schlosseri [PDF]
, 2015 Morula cells (MCs) represent the most abundant circulating hemocyte of the compound ascidian Botryllus schlosseri. They are cytotoxic cells involved in the rejection reaction between contacting, genetically incompatible colonies.
Ballarin, Loriano +2 more
core
Purinergic Signaling in Mast Cell Degranulation and Asthma
Frontiers in Pharmacology, 2017 Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors.
Zhang-Guo Gao, K. Jacobson
semanticscholar +1 more source