Results 61 to 70 of about 63,047 (307)

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Eosinophil secretion of granule-derived cytokines

Frontiers in Immunology, 2014
Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and sites of active tissue repair ...
Lisa A Spencer, Kennedy eBonjour, Rossana C.N. Melo, Peter F. Weller   +3 more
doaj   +1 more source

Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy

Cells, 2020
The NK cell population is characterized by distinct NK cell subsets that respond differently to the various activating stimuli. For this reason, the determination of the optimal cytotoxic activation of the different NK cell subsets can be a crucial ...
Loris Zamai, Genny Del Zotto, Flavia Buccella, Sara Gabrielli, Barbara Canonico, Marco Artico, Claudio Ortolani, Stefano Papa   +7 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Infection of Human Neutrophils With Leishmania infantum or Leishmania major Strains Triggers Activation and Differential Cytokines Release

Frontiers in Cellular and Infection Microbiology, 2019
Leishmaniases are neglected diseases, caused by intracellular protozoan parasites of the Leishmania (L.) genus. Although the principal host cells of the parasites are macrophages, neutrophils are the first cells rapidly recruited to the site of parasites
Rafeh Oualha, Rafeh Oualha, Mourad Barhoumi, Soumaya Marzouki, Emna Harigua-Souiai, Melika Ben Ahmed, Ikram Guizani   +6 more
doaj   +1 more source

Enhanced Hemocompatibility via Bivalirudin and Bicarbonate as Alternative to Heparin in a Catheter‐Based Axial‐Flow System

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Cardiovascular therapeutic devices typically require systemic heparin due to underlying thrombotic risk. The Impella axial flow system further relies on internal perfusion with either a heparin‐containing or sodium bicarbonate purge solution during operation.
Kaitlyn R. Ammann, Christine E. Outridge, Tiana Silver, Sami Muslmani, Jun Ding, Vladimir Gilman, Scott Corbett, Marvin J. Slepian   +7 more
wiley   +1 more source

Degranulation of leukocytes in chronic granulomatous disease [PDF]

, 1969
Robert L. Baehner, Morris J. Karnovsky, Manfred L. Karnovsky   +2 more
openalex   +2 more sources

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Frontiers in Cellular Neuroscience, 2019
Extracellular ATP activates inflammasome and triggers the release of multiple cytokines in various immune cells, a process primarily mediated by P2X7 receptors.
Dilyara Nurkhametova, Dilyara Nurkhametova, Igor Kudryavtsev, Igor Kudryavtsev, Valeriia Guselnikova, Valeriia Guselnikova, Maria Serebryakova, Raisa R. Giniatullina, Sara Wojciechowski, Fatma Tore, Albert Rizvanov, Jari Koistinaho, Jari Koistinaho, Tarja Malm, Rashid Giniatullin, Rashid Giniatullin   +15 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

Frontiers in Cellular and Infection Microbiology
SARS-CoV-2–induced excessive inflammation in brain leads to damage of blood–brain barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory cytokines by brain microvascular endothelial cells and microglia is reported to be
Meng-Li Wu, Chengzuo Xie, Chengzuo Xie, Xin Li, Jing Sun, Jincun Zhao, Jian-Hua Wang, Jian-Hua Wang, Jian-Hua Wang   +8 more
doaj   +1 more source