Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry [PDF]
Frontiers in PharmacologyDeguelin is a natural isoflavone derived from the rotenone family, commonly found in plants belonging to the Derris and Grifola genera. Comprehensive research has underscored its considerable promise in oncological treatment.
Wenjie Jiang +4 more
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Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway [PDF]
Cancer Management and ResearchSeunghee Bae,1 Sowon Bae,1 Hee Su Kim,1 Ye Jin Lim,1 Gyeongmi Kim,2 In-Chul Park,2 Kyeong A So,3 Tae Jin Kim,3 Jae Ho Lee1 1Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, Republic of Korea; 2Division of Fusion Radiology Research ...
Bae S +8 more
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Variation in Rotenone and Deguelin Contents among Strains across Four Tephrosia Species and Their Activities against Aphids and Whiteflies [PDF]
Toxins, 2022 Botanical pesticides have received increasing attention for sustainable control of insect pests. Plants from the genus Tephrosia are known to produce rotenone and deguelin.
Peiwen Zhang +5 more
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Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice [PDF]
Gut MicrobesAcetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear.
Shenhai Gong +18 more
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Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice [PDF]
Neoplasia, 2005 We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight,
Ming You
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EBioMedicine, 2017 Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers.
Haidan Liu, Li Zhou
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Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
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BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. [PDF]
PLoS ONE, 2016 This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing of ERK 1/2 with siRNAs and inhibition of ERK1/2 with deguelin treatment in HeLa cells ...
Samra Hafeez +15 more
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Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. [PDF]
PLoS ONE, 2013 Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly ...
Yan-li Yang +6 more
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Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone [PDF]
Frontiers in Pharmacology, 2023 Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available.
María Balsera-Manzanero +12 more
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