Results 41 to 50 of about 1,094 (190)

Affinity Chromatography‐Based Assays for the Screening of Potential Ligands Selective for G‐Quadruplex Structures

ChemistryOpen, Volume 11, Issue 5, May 2022., 2022
Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella, Ettore Napolitano, Claudia Riccardi, Domenica Musumeci, Daniela Montesarchio   +4 more
wiley   +1 more source

Nitrogen use efficiency, rhizosphere bacterial community, and root metabolome reprogramming due to maize seed treatment with microbial biostimulants

Physiologia Plantarum, Volume 174, Issue 2, March/April 2022., 2022
Abstract Seed inoculation with beneficial microorganisms has gained importance as it has been proven to show biostimulant activity in plants, especially in terms of abiotic/biotic stress tolerance and plant growth promotion, representing a sustainable way to ensure yield stability under low input sustainable agriculture. Nevertheless, limited knowledge
Paola Ganugi, Andrea Fiorini, Federico Ardenti, Tito Caffi, Paolo Bonini, Eren Taskin, Edoardo Puglisi, Vincenzo Tabaglio, Marco Trevisan, Luigi Lucini   +9 more
wiley   +1 more source

Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity

Journal of Clinical Laboratory Analysis, Volume 36, Issue 1, January 2022., 2022
Studying 400 T2DM patients without complication indicated: In T2DM patients without complication, the GPx and TAC levels decreased and the MDA level elevated. T2DM with neuropathy had lower levels of GSH, GPx, and TAC and higher levels of TOS, MDA, and OSI and a higher frequency of Keap1 AA genotype.
Farnaz Khalili, Asad Vaisi‐Raygani, Ebrahim Shakiba, Maryam Kohsari, Maryam Dehbani, Rozita Naseri, Soheila Asadi, Ziba Rahimi, Mehrali Rahimi, Zohreh Rahimi   +9 more
wiley   +1 more source

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Deguelin is a natural rotenoid that shows anti-inflammatory and antimicrobial activities. Rotenoids prevent oxidative damage and potentiate natural antioxidant activity in diabetic conditions, suggesting utility in treating diabetes and ...
Ji Chen, Wenjie Liu, Han Yi, Xiaoling Hu, Liangyu Peng, Fengrui Yang   +5 more
doaj   +1 more source

Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer.
Gui-hua Lai, Fei Wang, Duo-rui Nie, Shu-jun Lei, Zhuo-jun Wu, Jian-xiong Cao, Lan-lan Tang, Maria Grazia Ferraro   +7 more
wiley   +1 more source

In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection

Biology, 2022
Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to ...
Adrián Vicente-Barrueco, Ángel Carlos Román, Trinidad Ruiz-Téllez, Francisco Centeno   +3 more
doaj   +1 more source

Research Status of Mouse Models for Non‐Small‐Cell Lung Cancer (NSCLC) and Antitumor Therapy of Traditional Chinese Medicine (TCM) in Mouse Models

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Non‐small‐cell lung cancer (NSCLC) is known as one of the most lethal cancers, causing more than 1 million deaths annually worldwide. Therefore, the development of novel therapeutic drugs for NSCLC has become an urgent need. Herein, various mouse models provide great convenience not only for researchers but also for the development of antitumor drug ...
Hongkui Chen, Min Zheng, Wenhui Zhang, Yuan Long, Yu Xu, Man Yuan, Atul Kabra   +6 more
wiley   +1 more source

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

, 2017
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively
Korhonen, Pasi K., Gijs, Martin AM, Pasi K. Korhonen, Matteo Cornaglia, Auwerx, Johan, Paul W. Sternberg, Simon Crawford, Chang, Bill CH, Preston, Sarah, Cameron Nowell, Andreas Hofmann, Fisher, Gillian, Johan Auwerx, Korhonen, Pasi K, Mcgee, Sean L., Brendan R. E. Ansell, Mouchiroud, Laurent, Jabbar, Abdul, Ansell, Brendan R. E., Gasser, Robin, Young, Neil, Davis, Rohan, Gasser, Robin B, Chang, Bill C. H., Andrews, Katherine T., Laurent Mouchiroud, Abdul Jabbar, Baell, Jonathan, Rohan A. Davis, Sean L. McGee, Bill C. H. Chang, Young, Neil D, Korhonen, Pasi, Gillian M. Fisher, McGee, Sean, Neil D. Young, Jonathan Baell, Fisher, Gill, Sternberg, Paul W, Gijs, Martin A. M., Andrews, Katherine T, Davis, Rohan A., Fisher, Gillian M., Ansell, Brendan, Crawford, Simon, Nowell, Cameron, Cornaglia, Matteo, Sternberg, Paul, Gasser, Robin B., Katherine T. Andrews, Robin B. Gasser, Sarah Preston, Hofmann, Andreas, Chang, Bill, Martin A. M. Gijs, Young, Neil D., McGee, Sean L, Andrews, Katherine, Davis, Rohan A, Sternberg, Paul W., Fisher, Gillian M, Ansell, Brendan RE, Gijs, Martin   +62 more
core   +3 more sources

Larvicidal Activity of Isoflavonoids from Extracts Against

Natural Product Communications, 2012
The biological activity of extracts from the leaves, bark and roots of Muellera frutescens , an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides.
Charlotte Nirma, Alice M S. Rodrigues, Charlie Basset, Lionel Chevolot, Romain Girod, Christian Moretti, Didier Stien, Isabelle Dusfour, Véronique Eparvier   +8 more
doaj   +1 more source

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

Biomedicines, 2020
Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment ...
Sung-Jun Hong, Jin-Tae Kim, Su-Jung Kim, Nam-Chul Cho, Kyeojin Kim, Seungbeom Lee, Young-Ger Suh, Kyung-Cho Cho, Kwang Pyo Kim, Young-Joon Surh   +9 more
doaj   +1 more source