Stereocontrolled semi-syntheses of deguelin and tephrosin [PDF]
Organic & Biomolecular Chemistry, 2017 We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii .
Russell, David A +4 more
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Prediction of new C-terminal Hsp90 inhibitors based on deguelin scaffold: homology modeling, virtual screening, QM/MM docking, MM/GBSA, and molecular dynamics simulations [PDF]
Research in Pharmaceutical SciencesBackground and purpose: The N-terminal Hsp90 inhibitors are promising targets for cancer treatment; however, inducing the heat shock response is one of the most significant limitations.
Maryam Abbasi +2 more
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Deguelin inhibits perineural invasion in esophageal squamous cell carcinoma via targeting BDNF/TrkB axis [PDF]
Cancer Biology & TherapyBackground Perineural invasion (PNI) represents a uniquely distinctive pathway for tumor metastasis, but its underlying molecular mechanisms and therapy remain unclear.Methods Bioinformatics analysis and transcriptomic sequencing were first employed to ...
Qiying Wei +7 more
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Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis.
Shanshan Li +10 more
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The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Eain Murphy +2 more
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Molecules, 2014 Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic
Hung-Sheng Shang +2 more
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Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Cancer Management and Research, 2018 Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L +8 more
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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Pharmacological Research, 2021 Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural rotenoid, is among the class of bioactive phytoconstituents from a diverse range of plants with potential antineoplastic effects in ...
Hardeep Singh Tuli +11 more
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Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS ONE, 2013 BackgroundTreatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast cancers respectively.
Rajeshwari Mehta +7 more
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [PDF]
Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
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