Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis [PDF]
Cell Death and DiseaseRadioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and that FBXO22 knockdown increased the ...
Yunshang Chen +12 more
doaj +2 more sources
Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin [PDF]
International Journal of Molecular Sciences, 2016 Pancreatic cancer is the fourth most common cause of cancer mortality worldwide. Furthermore, patients with pancreatic cancer experience limited benefit from current chemotherapeutic approaches because of drug resistance. Therefore, an effective therapeutic strategy for patients with pancreatic cancer is urgently required.
Xiao-Dong Xu +12 more
openaire +4 more sources
Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation [PDF]
Cell Death and DiseaseCutaneous squamous carcinoma is the second most common epithelial malignancy, associated with significant morbidity, mortality, and economic burden. However, the mechanisms underlying cSCC remain poorly understood.
Kaili Zhou +10 more
doaj +2 more sources
Inhibitory Effects of B‑, C‑, and E‑Ring-Truncated Deguelin Derivatives Against A549, HCT116, and MCF‑7 Cancer Cells [PDF]
ACS Omega, 2023 John Alfon P. Francisco +1 more
doaj +2 more sources
Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway. [PDF]
Dis Markers, 2022 Non‐small‐cell lung cancer (NSCLC) is the most common lung cancer and a major cause of cancer mortality worldwide. Deguelin plays a vital inhibitory role in NSCLC initiation and development. However, the downstream mechanism of deguelin‐suppressed metastasis of NSCLC cells is still not completely understood.
Lu G, Yao Y, Zhang X, Cui D, Zhou J.
europepmc +2 more sources
Novel insights into immunopathogenesis and crucial biomarkers between primary open-angle glaucoma and systemic lupus erythematosus. [PDF]
IMetaOmicsThis study revealed a novel correlation between systemic lupus erythematosus (SLE) and primary open‐angle glaucoma (POAG) through comprehensive bioinformatics analysis and experimentation, identifying biomarkers and immunopathogenesis for future research and treatment of SLE‐related POAG.
Liu Y +5 more
europepmc +2 more sources
Amelioration of an undesired action of deguelin [PDF]
Toxicon, 2013 The pharmaceutical world has greatly benefited from the well-characterized structure-function relationships of toxins with endogenous biomolecules, such as ion-channels, receptors, and signaling molecules. Thus, therapeutics derived from toxins have been aggressively pursued.
Julie A, Vrana +3 more
openaire +2 more sources
Mitochondrial DNA mutations in ageing and cancer
Molecular Oncology, Volume 16, Issue 18, Page 3276-3294, September 2022., 2022 Mitochondrial DNA mutations are a common feature of ageing tissues and a number of human cancers. They can affect essential mitochondrial functions such as oxidative phosphorylation, redox balance, apoptosis, and numerous biosynthetic pathways. These are important mechanisms which reportedly impact tumour growth, though data are often contradictory ...
Anna L. M. Smith +2 more
wiley +1 more source
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. [PDF]
PLoS ONE, 2016 B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement achieved by therapeutic regimes developed over the last years still a subset of patients face a rather poor prognosis and will eventually relapse and ...
Nerea Rebolleda +9 more
doaj +1 more source
A review on invasive false indigo bush (Amorpha fruticosa L.): Nuisance plant with multiple benefits
Ecology and Evolution, Volume 12, Issue 9, September 2022., 2022 Amorpha fruticosa L. represents an invasive plant causing a nuisance and degrading native biodiversity on a variety of wet and mesic habitats throughout the Northern Hemisphere. On the other hand, the plant species possesses numerous beneficial applications including phytochemical and biocoenotic uses, as well as ecosystem services.
Jasna Grabić +4 more
wiley +1 more source