Results 51 to 60 of about 2,864 (172)

All‐Oral Shorter Treatment Regimens for Multidrug‐ and Rifampicin‐Resistant Tuberculosis: Evaluating Their Effectiveness, Safety, and Impact on the Quality of Life of Patients in Lao PDR

Tropical Medicine &International Health, Volume 30, Issue 12, Page 1340-1353, December 2025.
ABSTRACT Background Drug‐resistant tuberculosis remains a major public health challenge in Lao PDR, with low second‐line treatment uptake and suboptimal outcomes. To improve effectiveness, safety, and tolerability, a shorter all‐oral regimen for multidrug‐ and rifampicin‐resistant tuberculosis (MDR/RR‐TB) was introduced under the TDR Short, all‐Oral ...
Vibol Iem, Sakhone Suthepmany, Vongkham Inthavong, Anousone Sisouvanh, Khamloun Choumlivong, Kyung Hyun Oh, Philipp du Cros, Fatimata Bintou Sall, Corinne S. Merle, Jacques Sebert, Donekham Inthavong   +10 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Effectiveness and safety of regimen containing bedaquiline and delamanid in patients with drug-resistant tuberculosis

Perspectives in Clinical Research
Background: Bedaquiline and delamanid have been included in the individualized treatment regimen (ITR) to treat patients with drug-resistant tuberculosis (DR-TB).
Oki Nugraha Putra, Yulistiani Yulistiani, Soedarsono Soedarsono, Susi Subay   +3 more
doaj   +1 more source

Black Hairy Tongue as a Rare Adverse Effect of Linezolid in Multidrug‐Resistant Tuberculosis: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Black hairy tongue (BHT), or lingua villosa nigra, is a rare adverse effect of linezolid, an antibiotic frequently used in the treatment of multidrug‐resistant tuberculosis (MDR‐TB). We present a case of a 24‐year‐old female who developed BHT while receiving linezolid as part of a longer regimen for MDR‐TB.
Dipendra Adhikari, Salina Paudel, Munna William, Manoj Kumar Bhatt, Sanju Dahal, Abishkar Gautam, Binay Adhikari   +6 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

New drugs in the treatment of drug-resistant tuberculosis in children. Experience with the use of delamanid in combination with bedaquiline

Journal of Global Antimicrobial Resistance
OBJECTIVE: To determine the safety and effectiveness of delamanid in combination with bedaquiline in children for the treatment of multidrug-resistant tuberculosis. MATERIALS-METHODS: In 2023-2024, 18 children aged 3 to 17 years with MDR-TB were treated.
Ekaterina Sokolskaya, Nadezhda Klevno, Anastasiya Samoylova, Alexey Kazakov, Anastasiya Gaida   +4 more
doaj   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

The experience of using delamanid in the Chechen Republic

Tuberculosis and Lung Diseases, 2020
.
S. M. Lorsanov, Z. B. Khaydarkhanova, S. B. Khunkarsultanov   +2 more
openaire   +3 more sources

Machine Learning‐Based High‐Throughput Screening, Molecular Modeling and Quantum Chemical Analysis to Investigate Mycobacterium tuberculosis MetRS Inhibitors

ChemistryOpen, Volume 14, Issue 7, July 2025.
This paper provides a comprehensive approach using the ChEMBL database to construct a machine learning model that screened 10 million compounds from the eMolecules database. Two promising inhibitors targeting Mycobacterium tuberculosis methionyl‐tRNA synthetase were identified.
Rajesh Maharjan, Kalpana Gyawali, Arjun Acharya, Madan Khanal, Kamal Khanal, Mohan Bahadur Kshetri, Madhav Prasad Ghimire, Tika Ram Lamichhane   +7 more
wiley   +1 more source

Establishing the Exposure‐QT Relationship During Bedaquiline Treatment Using a Time‐Varying Tuberculosis‐Specific Correction Factor (QTcTBT)

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1252-1261, July 2025.
ABSTRACT Evaluating QT prolongation induced by anti‐tuberculosis (TB) drugs in patients with active TB, who often experience tachycardia, is challenging due to the limitations of Fridericia's correction factor (QTcF) in decorrelating QTc from heart rate (HR).
Thanakorn Vongjarudech, Anne‐Gaëlle Dosne, Bart Remmerie, Mats O. Karlsson, Elin M. Svensson   +4 more
wiley   +1 more source