Results 41 to 50 of about 3,657 (192)

Effectiveness and cardiovascular safety of delamanid-containing regimens in adults with multidrug-resistant or extensively drug-resistant tuberculosis: A nationwide cohort study from Belarus, 2016-18

Monaldi Archives for Chest Disease, 2021
To address the sub-optimal treatment outcomes among patients with multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), the National TB Programme in Belarus started using new drugs such as bedaquiline and delamanid in 2015-16.
Vera Auchynka, Ajay M.V. Kumar, Hennadz Hurevich, Yuliia Sereda, Varvara Solodovnikova, Dzmitry Katovich, Svetlana Setkina, Askar Yedilbayev, Aliaksandr Skrahin, Alena Skrahina   +9 more
doaj   +1 more source

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

, 2019
<p>Tuberculosis (TB) is the most deadly infectious disease worldwide. To reduce TB incidence and counter the</p> <p>spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the</p&
A. Sury, O. Sismeiro, H. Varet, Mathys, Vanessa, V. Mathys, A. Van den Bossche, J.Y. Coppee, Sismeiro, Odile, Sury, Amandine, R. Legendre, P.J. Ceyssens, Legendre, Rachel, Coppée, Jean-Yves, Varet, Hugo, van den Bossche, An, Ceyssens, Pieter-Jan   +15 more
core   +1 more source

Culture conversion at six months in patients receiving bedaquiline- and delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

International Journal of Infectious Diseases, 2021
Rifampicin-resistant/multidrug-resistant (RR/MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis (TB) are serious public health problem in Kazakhstan.
Shynar M. Maretbayeva, Anar S. Rakisheva, Malik M. Adenov, Lyazzat T. Yeraliyeva, Yerkebulan Zh. Algozhin, Assel T. Stambekova, Elmira A. Berikova, Askar Yedilbayev, Michael L. Rich, Kwonjune J. Seung, Assiya M. Issayeva   +10 more
doaj   +1 more source

Use of Short Oral Regimens for Treatment of Drug Resistant Tuberculosis in a Patient with HIV Infection

Туберкулез и болезни лёгких, 2023
We present the clinical case of effective treatment of tuberculosis in a patient with disseminated pulmonary and extrapulmonary pre-extensive drug resistant tuberculosis, HIV-infection and other severe opportunistic and concomitant infections.
S. Yu. Degtyareva, T. A. Kuznetsova, V. N. Zimina   +2 more
doaj   +1 more source

Frequency of Resistance to Delamanid in Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis in the Russian Federation

Антибиотики и Химиотерапия
Delamanid is one of the key new drugs for the treatment of multidrug-resistant and, in particular, extensively drug-resistant tuberculosis. However, due to its relatively recent introduction into clinical practice, data on the frequencу of resistance ...
S. N. Andreevskaya, T. G. Smirnova, E. E. Larionova, E. A. Kiseleva, Yu. V. Maslennikova, L. N. Chernousova, A. E. Ergeshov   +6 more
doaj   +1 more source

Evaluation of the effectiveness of bedaquiline and delamanid treatment among children and adolescents with multi-drug-resistant pulmonary tuberculosis

Сучасна педіатрія: Україна, 2023
Introduction. Against the backdrop of multiple and widespread drug resistance of Mycobacterium tuberculosis (MDR-TB), there has been a significant decline in the effectiveness of treatment of tuberculosis (TB) patients in Ukraine and globally. Therefore,
M.I. Sakhelashvili, I.L. Platonova, O.I. Sakhelashvili-Bil, Z.I. Piskur   +3 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

MICs of pretomanid and delamanid against different mycobacterial strains.

, 2020
MICs of pretomanid and delamanid against different mycobacterial strains.
Livnat Afriat-Jurnou (2057317), Nicholas P. West (324121), Liam K. Harold (8423295), Htin Lin Aung (6068708), Colin J. Jackson (153786), Kiel Hards (6068705), Deepak V. Almeida (8423298), Chris Greening (603810), Brendon M. Lee (8423292), Matthew C. Taylor (153774), A. Elaaf Mohamed (3367181), Eric L. Nuermberger (188446), Scott A. Beatson (6694991), Brian M. Forde (8423301), Sacha J. Pidot (7865252), F. Hafna Ahmed (3367178), Timothy P. Stinear (143097), Gregory M. Cook (7319351)   +17 more
core   +1 more source

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Ankit, Audrey Jordaan, Digby F. Warner, Parvesh Singh   +8 more
wiley   +1 more source