Results 41 to 50 of about 2,864 (172)
Clinical Case Reports, Volume 14, Issue 3, March 2026.Coronal reconstruction post contrast thoraco‐abdominal CT of a 9 years old boy taken December, 2023. This shows 1.45 by 3.9 cms hypodense collection having rim enhancement in the right anterio‐inferior sub‐phrenic space suggestive of abscess. ABSTRACT Diagnosing extrapulmonary and drug‐resistant tuberculosis in children is challenging.
Animaw Lingerew +4 more
wiley +1 more source
Pharmacology and Clinical Pharmacy ResearchBackground: The cardiac safety of regimens containing bedaquiline and delamanid is not well-established, especially in Indonesia. This study aimed to analyze QTc interval during six months of treatment and factors associated with QTc interval ...
Oki Nugraha Putra
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová +9 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Tuberculosis (TB) is a major public health problem, with nearly 10 million new cases and millions of deaths each year. Around 10% of these cases are in children, but only a fraction receive proper diagnosis and treatment. The spread of drug-resistant (DR)
Hanzhao Zhu +9 more
doaj +1 more source
Protein Target Highlights in CASP16: Insights From the Structure Providers
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander +34 more
wiley +1 more source
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis [PDF]
New England Journal of Medicine, 2015 Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid.
Bloemberg, Guido V. +14 more
openaire +4 more sources
Extensive Lymphadenopathy in an HIV‐Negative Patient With Multidrug‐Resistant Tuberculosis
Respirology Case Reports, Volume 14, Issue 1, January 2026.Extensive lymphadenopathy is uncommon in HIV‐negative patients with tuberculosis. This clinical image highlights the striking CT appearance of extensive extrapulmonary lymph node involvement in symptomatic multidrug‐resistant tuberculosis, even in the absence of HIV infection. ABSTRACT Tuberculous lymphadenitis is generally more severe in patients with
Tomoyuki Araya +5 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Mean blood drug concentration–time curves (linear and semi‐logarithmic) of JBD0131 in the (A) single‐dose group; (B) food‐affected group. ABSTRACT This study evaluated the safety, tolerability, and pharmacokinetics of JBD0131, a novel nitroimidazooxazole antitubercular agent, in healthy adults.
Jia Miao +9 more
wiley +1 more source
Туберкулез и болезни лёгких, 2018 The article presents the review of current publications, clinical recommendations and guidelines written by foreign authors and devoted to treatment of drug resistant tuberculosis with delamanid.
Aleksey G. Naumov, Aleksandr V. Pavlunin
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Molecules, 2020 Nitroimidazole drugs have a long history as therapeutic agents to treat bacterial and parasitic diseases. The discovery in 1989 of a bicyclic nitroimidazole lead, displaying in vitro and in vivo antitubercular activity, spurred intensive exploration of ...
Hollis D. Showalter
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