Results 61 to 70 of about 3,657 (192)

Protein Target Highlights in CASP16: Insights From the Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander, Océane M. Follonier, Andriy Kryshtafovych, Kim Abesamis, Sabrina Bibi‐Triki, Henry G. Box, Cécile Breyton, Françoise Bringel, Loic Carrique, Alessio d'Acapito, Gang Dong, Rebecca DuBois, Deborah Fass, Juliana Martinez Fiesco, Daniel R. Fox, Jonathan M. Grimes, Rhys Grinter, Matthew Jenkins, Roman Kamyshinsky, Jeremy R. Keown, Gerald Lackner, Michael Lammers, Shiheng Liu, Andrew L. Lovering, Tomas Malinauskas, Benoît Masquida, Gottfried J. Palm, Christian Siebold, Tiantian Su, Ping Zhang, Z. Hong Zhou, Krzysztof Fidelis, Maya Topf, John Moult, Torsten Schwede   +34 more
wiley   +1 more source

Extensive Lymphadenopathy in an HIV‐Negative Patient With Multidrug‐Resistant Tuberculosis

Respirology Case Reports, Volume 14, Issue 1, January 2026.
Extensive lymphadenopathy is uncommon in HIV‐negative patients with tuberculosis. This clinical image highlights the striking CT appearance of extensive extrapulmonary lymph node involvement in symptomatic multidrug‐resistant tuberculosis, even in the absence of HIV infection. ABSTRACT Tuberculous lymphadenitis is generally more severe in patients with
Tomoyuki Araya, Toshiyuki Kita, Kazuhiko Iwasaki, Takayuki Higashi, Ryo Hara, Hazuki Takato   +5 more
wiley   +1 more source

Perspectives of targeted chemotherapy with delamanid in the treatment regimens of those with multiple/extensive drug resistant tuberculosis. A success, chance or uncertainty?

Туберкулез и болезни лёгких, 2018
The article presents the review of current publications, clinical recommendations and guidelines written by foreign authors and devoted to treatment of drug resistant tuberculosis with delamanid.
Aleksey G. Naumov, Aleksandr V. Pavlunin
doaj   +1 more source

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

Molecules, 2020
Nitroimidazole drugs have a long history as therapeutic agents to treat bacterial and parasitic diseases. The discovery in 1989 of a bicyclic nitroimidazole lead, displaying in vitro and in vivo antitubercular activity, spurred intensive exploration of ...
Hollis D. Showalter
doaj   +1 more source

Combating Drug‐Resistant Tuberculosis: Advancements in Diagnostics and Therapeutics

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
The increasing prevalence of multidrug‐resistant (MDR) and extensively drug‐resistant (XDR)Mycobacterium tuberculosis has emerged as a major global health concern. Advanced molecular diagnostics, including rapid assays, have improved resistance detection; however, resource‐limited settings remain underserved. Nanotechnology‐based drug delivery systems,
Silvi Gautam, Jahanvi Saini, Shabaaz Begum Jameel Pasha, Divakar Sharma, Divya Venugopal, Semonti Nandi   +5 more
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of a Novel Nitroimidazooxazole Antitubercular Agent in Healthy Adults: A Phase I Trial

MedComm, Volume 6, Issue 12, December 2025.
Mean blood drug concentration–time curves (linear and semi‐logarithmic) of JBD0131 in the (A) single‐dose group; (B) food‐affected group. ABSTRACT This study evaluated the safety, tolerability, and pharmacokinetics of JBD0131, a novel nitroimidazooxazole antitubercular agent, in healthy adults.
Jia Miao, Zhenling Wang, Zhenyu Ding, Huashan Shi, Yongping Qin, Tiantao Gao, Ning Jiang, Jianqing He, Manni Wang, Xiawei Wei   +9 more
wiley   +1 more source

New drugs in the treatment of drug-resistant tuberculosis in children. Experience with the use of delamanid in combination with bedaquiline

Journal of Global Antimicrobial Resistance
OBJECTIVE: To determine the safety and effectiveness of delamanid in combination with bedaquiline in children for the treatment of multidrug-resistant tuberculosis. MATERIALS-METHODS: In 2023-2024, 18 children aged 3 to 17 years with MDR-TB were treated.
Ekaterina Sokolskaya, Nadezhda Klevno, Anastasiya Samoylova, Alexey Kazakov, Anastasiya Gaida   +4 more
doaj   +1 more source

All‐Oral Shorter Treatment Regimens for Multidrug‐ and Rifampicin‐Resistant Tuberculosis: Evaluating Their Effectiveness, Safety, and Impact on the Quality of Life of Patients in Lao PDR

Tropical Medicine &International Health, Volume 30, Issue 12, Page 1340-1353, December 2025.
ABSTRACT Background Drug‐resistant tuberculosis remains a major public health challenge in Lao PDR, with low second‐line treatment uptake and suboptimal outcomes. To improve effectiveness, safety, and tolerability, a shorter all‐oral regimen for multidrug‐ and rifampicin‐resistant tuberculosis (MDR/RR‐TB) was introduced under the TDR Short, all‐Oral ...
Vibol Iem, Sakhone Suthepmany, Vongkham Inthavong, Anousone Sisouvanh, Khamloun Choumlivong, Kyung Hyun Oh, Philipp du Cros, Fatimata Bintou Sall, Corinne S. Merle, Jacques Sebert, Donekham Inthavong   +10 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Black Hairy Tongue as a Rare Adverse Effect of Linezolid in Multidrug‐Resistant Tuberculosis: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Black hairy tongue (BHT), or lingua villosa nigra, is a rare adverse effect of linezolid, an antibiotic frequently used in the treatment of multidrug‐resistant tuberculosis (MDR‐TB). We present a case of a 24‐year‐old female who developed BHT while receiving linezolid as part of a longer regimen for MDR‐TB.
Dipendra Adhikari, Salina Paudel, Munna William, Manoj Kumar Bhatt, Sanju Dahal, Abishkar Gautam, Binay Adhikari   +6 more
wiley   +1 more source