Results 81 to 90 of about 3,657 (192)

Delamanid and its Role in Drug-Resistant Tuberculosis

, 2017
The World Health Organisation estimates that one-third of the world's population are currently infected with Tuberculosis bacillus, 10% of whom will develop the disease at some point in their lifetime.
Supratik Das, Vijay Kumar Sehgal
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Delamanid expanded access novel treatment of drug resistant tuberculosis

Infection and Drug Resistance, 2015
Roxana Rustomjee,1 Alimuddin Zumla2,31South African Medical Research Council, Cape Town, South Africa; 2Division of Infection and Immunity, University College London, London, UK; 3NIHR Biomedical Research Centre, University College Hospitals NHS ...
Rustomjee R, Zumla A
doaj  

Identification of Patients Who Could Benefit from Bedaquiline or Delamanid: a Multisite MDR-TB Cohort Study

, 2016
The World Health Organization recommends adding bedaquiline or delamanid to multidrug-resistant tuberculosis (MDR-TB) regimens for which four effective drugs are not available, and delamanid for patients at high risk of poor ...
Telnov, A, Hayrapetyan, A, Hewison, C, Khamraev, A, Bonnet, M, Themba, D, Kimenye, K, Bastard, M, Varaine, F, Khurkhumal, S, du Cros, P, Sanchez-Padilla, E   +11 more
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Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naive patients.

, 2020
Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance.
Anchalee Avihingsanon (340691), Erik C Böttger (8156481), Jimena Collantes (3808612), Sebastien Gagneux (149824), Peter M Keller (8156463), Miriam Reinhard (6181745), Matthias Egger (24558), International epidemiology Databases to Evaluate AIDS (IeDEA) (9556580), Rico Hömke (6181736), Robert J Wilkinson (8128959), Sonia Borrell (149821), Martina L Reichmuth (9556577), Chloé Loiseau (3331821), Lukas Fenner (149822), Peter Sander (52096), Kathrin Zürcher (1807825), Marcel Yotebieng (349839)   +16 more
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Bedaquiline, Delamanid, Linezolid, Clofazimine, and Capreomycin MIC Distributions for Drug Resistance Mycobacterium tuberculosis in Shanghai, China

Infection and Drug Resistance, 2023
Yinjuan Guo,1 Jinghui Yang,1 Weiping Wang,1 Xiaocui Wu,1 Baoshan Wan,1 Hongxiu Wang,1 Wei Sha,2 Fangyou Yu1 1Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China ...
Guo Y, Yang J, Wang W, Wu X, Wan B, Wang H, Sha W, Yu F   +7 more
doaj  

Interim outcomes of delamanid for the treatment of MDR- and XDR-TB in South Korea

, 2017
Objectives: Delamanid is a new anti-TB drug, but few data exist on its use outside clinical trials. The purpose of this study was to evaluate the efficacy as well as the safety and tolerability of a delamanid-containing regimen for 24 weeks in the ...
Won-Jung Koh, Mok, Jeongha, Doosoo Jeon, Park, Jin Su, Soo Hee Hwang, Bohyoung Kang, Jin Su Park, Jeongha Mok, Hyungseok Kang, Hwang, Soo Hee, Jeon, Doosoo, Jae-Joon Yim, Lee, Taehoon, Yim, Jae-Joon, Taehoon Lee, Kang, Hyungseok, Kang, Bohyoung, Koh, Won-Jung   +17 more
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CRISPR Screening and Comparative LC‐MS Analysis Identify Genes Mediating Efficacy of Delamanid and Pretomanid against Mycobacterium tuberculosis

Advanced Science
Tuberculosis (TB), the leading cause of death from bacterial infections worldwide, results from infection with Mycobacterium tuberculosis (Mtb). The antitubercular agents delamanid (DLM) and pretomanid (PMD) are nitroimidazole prodrugs that require ...
Mei‐Yi Yan, Haifeng Li, Yun‐Mo Qu, Si‐Shang Li, Dandan Zheng, Xiao‐Peng Guo, Zhaojun Wu, Jie Lu, Yu Pang, Weimin Li, Jian Yang, Lingjun Zhan, Yi‐Cheng Sun   +12 more
doaj   +1 more source

SIMULTANEOUS ESTIMATION OF DELAMANID AND BEDAQUILINE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC

A simple, accurate, precise, and economical RP-HPLC method was developed and validated for the simultaneous estimation of Delamanid and Bedaquiline in bulk drug and pharmaceutical dosage forms. Chromatographic separation was achieved using a Kromasil C18
Nagaraju P, Srinivas N
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Delamanid for the treatment of patients with resistant tuberculosis [PDF]

, 2019
El objetivo es evaluar la eficacia y seguridad, así como documentos relacionados a la decisión de cobertura del delamanid para tuberculosis ...
Calderón Cahua, María
core  

Bedaquiline and delamanid for the treatment of multidrug-resistant tuberculosis: a multicentre cohort study in Korea

, 2018
Relatively little is known about the efficacy and safety of the programmatic use of bedaquiline and delamanid in multidrug-resistant tuberculosis (MDR-TB) treatment.This study evaluated 61 patients with MDR-TB treated with bedaquiline (n=39), delamanid ...
Cheon Tae Kim, Yong-Soo Kwon, Hong-Joon Shin, Tae-Ok Kim, Yeong Hun Choe, Hak-Ryul Kim, Young Chun Ko   +6 more
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