Results 141 to 150 of about 33,878 (250)

Anti-diabetic medications to fight Parkinson's disease and dementia with Lewy bodies: a pilot study. [PDF]

Front Neurol
Chmiela T, Dulski J, Heckman MG, Fang ZJ, Wszolek ZK, Wilson JR.   +5 more
europepmc   +1 more source

Progression to Dementia in Very Late‐Onset Schizophrenia‐Like Psychosis Stratified by Alzheimer's Disease and Lewy Body Disease Biomarkers: A Retrospective Cohort Study

Psychogeriatrics, Volume 26, Issue 5, September 2026.
ABSTRACT Background Very late‐onset schizophrenia‐like psychosis (VLOSLP) is clinically heterogeneous, and its relationship with dementia‐related neurodegenerative disease remains unresolved. We examined whether Alzheimer's disease (AD) and Lewy body disease (LBD) biomarker status were associated with dementia progression in VLOSLP.
Yuto Satake, Hideki Kanemoto, Daiki Taomoto, Kayo Takeda, Shigeki Katakami, Matasaburo Kobayashi, Keiko Matsunaga, Kayako Isohashi, Takashi Suehiro, Kenji Yoshiyama, Manabu Ikeda   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, Volume 16, Issue 8, Page 1563-1592, August 2026.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies: The Role of Dysautonomia. [PDF]

Neurology
Mahajan A, Dwivedi AK, Galvin JE, Maixner SM, Paulson HL, Manning CA, Fields JA, Boeve BF, Mills KA, Morrow C, Pontone GM, Armstrong MJ.   +11 more
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1569-1580, August 2026.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1719-1725, August 2026.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Skeletal muscle loss is associated with cognitive decline, but whether neuroimaging‐derived muscle characteristics predict incident dementia remains unclear. METHODS We evaluated associations of deep learning–derived temporalis muscle (TM) cross‐sectional area (CSA) and radiomic texture features from baseline T1‐weighted magnetic ...
Kamyar Moradi, Roham Hadidchi, Amyn Majbri, Timothy M. Hughes, Hanzhang Lu, Yuxin Zhu, Soheil Mohammadi, Sara Momtazmanesh, Pratik Mukherjee, Muhammad Abdullah, Eleanor Simonsick, Jennifer A. Schrack, Marcus D. Goncalves, Josef Coresh, Marilyn Albert, Shadpour Demehri   +15 more
wiley   +1 more source

Locus coeruleus alterations in dementia with Lewy bodies: A systematic review. [PDF]

Alzheimers Dement (N Y)
Bain A, Tomeo C, André C, Garnier-Crussard A, de Flores R, Dautricourt S.   +5 more
europepmc   +1 more source

Characterization of [18F]SMBT‐1 binding substrates in Alzheimer's disease and related disorders: A postmortem biochemical and immunohistochemical study

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Neuroimaging studies report associations of amyloid beta (Aβ) positron emission tomography (PET) with [18F](S)‐(2‐methylpyrid‐5‐yl)‐6‐[(3‐fluoro‐2‐hydroxy)propoxy]quinoline ([18F]SMBT‐1), a novel reactive astrogliosis surrogate radiotracer with high affinity for monoamine oxidase B (MAO‐B) in Alzheimer's disease (AD).
Eric E. Abrahamson, Julia K. Kofler, Oscar L. Lopez, Anne D. Cohen, Alexandra Gogola, Howard J. Aizenstein, Thomas K. Karikari, Elliott J. Mufson, Victor L. Villemange, Milos D. Ikonomovic   +9 more
wiley   +1 more source

Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study. [PDF]

NPJ Parkinsons Dis
Habich A, Baumann JM, Schwarz CG, Przybelski SA, Inguanzo A, Oppedal K, Blanc F, Lemstra AW, Hort J, Boeve BF, Aarsland D, Westman E, Dierks T, Kantarci K, Jonkman LE, Ferreira D.   +15 more
europepmc   +1 more source