Results 121 to 130 of about 95,899 (339)
Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase [PDF]
, 2000 An Acinetobacter sp. genetic screen was used to probe structure-function relationships in vanillate demethylase, a two-component monooxygenase. Mutants with null, leaky, and heat-sensitive phenotypes were isolated.
Morawski, Birgit +2 more
core
Cell Host and Microbe, 2019 Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients.
Kun Chen +16 more
semanticscholar +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Trithorax group proteins: switching genes on and keeping them active [PDF]
, 2011 Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G. +3 more
core +1 more source
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA
Cell Research, 2020 N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation.
Min Zhang +9 more
semanticscholar +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio +20 more
core +3 more sources
The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity.
Journal of Clinical Investigation, 2019 Multiple sclerosis (MS) is a putative T cell-mediated autoimmune disease. As with many autoimmune diseases, females are more susceptible than males. Sexual dimorphisms may be due to differences in sex hormones, sex chromosomes, or both.
Y. Itoh +7 more
semanticscholar +1 more source
Advances in Histone Demethylase KDM3A as a Cancer Therapeutic Target
Cancers, 2020 Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1 histone demethylases that promote gene expression. The KDM3 subfamily primarily consists of four proteins (KDM3A−D). All four proteins contain the catalytic Jumonji C domain (
Jung Yoo +6 more
semanticscholar +1 more source
HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: EFFECT OF CYANIDE ON MICROSOMAL N-DEMETHYLASE ACTIVITY
Japanese Journal of Pharmacology, 1977 Cyanide, an inhibitor of many hemoproteins, was shown to affect a number of microsomal drug-metabolizing activities catalyzed by cytochrome P-450. The N-demethylation reaction of aminopyrine was inhibited noncompetitively by this inhibitor in microsomal preparations from rats.
T, Matsubara, A, Touchi
openaire +3 more sources