Results 151 to 160 of about 98,772 (389)
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
Cancers, 2019 Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy.
B. Majello +3 more
semanticscholar +1 more source
Losing the maternal effect gene Nlrp2 alters the ovulated mouse oocytes transcriptome and impacts histone demethylase KDM1B expression [PDF]
, 2022 Zahra Anvar +8 more
openalex +1 more source
Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3
Biochemistry and Biophysics Reports, 2016 Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation.
Yuko Ueda +8 more
doaj +1 more source
Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase [PDF]
, 2000 An Acinetobacter sp. genetic screen was used to probe structure-function relationships in vanillate demethylase, a two-component monooxygenase. Mutants with null, leaky, and heat-sensitive phenotypes were isolated.
Morawski, Birgit +2 more
core
The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis[OPEN]
The Plant Cell, 2019 Age-dependent downregulation of JMJ16, a specific H3K4 demethylase, is required for epigenetic reprograming of senescence-associated gene expression during leaf senescence. Leaf senescence is governed by a complex regulatory network involving the dynamic
Peng Liu +10 more
semanticscholar +1 more source
Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells [PDF]
, 2023 Junpeng Huang +11 more
openalex +1 more source
Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Relation between TMAOase activity and content of formaldehyde in fillet minces and bellyflap minces from gadoid fishes [PDF]
, 1997 Minced fish is a significant component of a number of frozen fishery products like fish fingers, cakes and patties. Predominately minced fish is produced from gadoid species (Alaska pollack, cod, saithe, hake and others) possessing the enzyme ...
Gonzales-Sotelo, C. +6 more
core
Advanced Science, EarlyView.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source