Results 151 to 160 of about 7,855 (246)

METTL16 and YTHDC1 Regulate Spermatogonial Differentiation via m6A

Cell Proliferation, EarlyView.
The deletion of either Mettl16 or Ythdc1 with Stra8‐Cre disrupted the gene expression related to chromosome organisation and segregation, resulting in aberrant differentiation of spermatogonia and male infertility. ABSTRACT Spermatogenesis is a highly unique and intricate process, finely regulated at multiple levels, including post‐transcriptional ...
Xueying Gu, Xinyuan Dai, Haifeng Sun, Yilong Lian, Xingxu Huang, Bin Shen, Pengfei Zhang   +6 more
wiley   +1 more source

Mitonuclear Communication in Stem Cell Function

Cell Proliferation, EarlyView.
In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley   +1 more source

G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate [PDF]

, 2003
L Rodero, Emilia Mellado, Angelica Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca‐Estrella, Graciela Davel, Juan L. Rodrı́guez-Tudela   +8 more
openalex   +1 more source

Organoids in Haematologic Research: Advances and Future Directions

Cell Proliferation, EarlyView.
This review focuses on the advancements in organoid technology and its transformative role in haematological research, particularly in the modelling of haematopoietic tissues, blood diseases and drug development. It also offers an outlook on the future prospects of organoids in personalised medicine and the study of disease mechanisms.
Liangzheng Chang, Lu Li, Yuling Han, Hui Cheng, Liuliu Yang   +4 more
wiley   +1 more source

Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase [PDF]

, 2003
Paul A. Mann, Raulo Parmegiani, Shui-Qing Wei, Cara Mendrick, Xin Li, David Loebenberg, Beth DiDomenico, R S Hare, Scott S. Walker, Paul M. McNicholas   +9 more
openalex   +1 more source

tRF‐3a‐Pro: A Transfer RNA‐Derived Small RNA as a Novel Biomarker for Diagnosis of Hepatitis B Virus‐Related Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
tRF‐3a is the main tsRNA subtype up‐regulated in HBV‐related HCC. tRF‐3a‐Pro is significantly up‐regulated in HBV‐related HCC tumour than that in paratumour tissues. The level of tRF‐3a‐Pro in serum is a promising candidate biomarker for HCC diagnosis. tRF‐3a‐Pro promotes cell proliferation and regulates cell cycle of HCC.
Jingyi Si, Yanting Zou, Yifan Gao, Jia Chen, Wei Jiang, Xizhong Shen, Changfeng Zhu, Qunyan Yao   +7 more
wiley   +1 more source

Coexistence of Two Different O Demethylation Systems in Lignin Metabolism by Sphingomonas paucimobilis SYK-6: Cloning and Sequencing of the Lignin Biphenyl-Specific O -Demethylase (LigX) Gene

, 2000
Tomonori Sonoki, Takahiro Obi, Sachiko Kubota, Motoo Higashi, Eiji Masai, Yoshihiro Katayama   +5 more
openalex   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

A Novel Tetrahydrofolate-Dependent O -Demethylase Gene Is Essential for Growth of Sphingomonas paucimobilis SYK-6 with Syringate [PDF]

, 2004
Eiji Masai, Sasaki Miyuki, Yasunori Minakawa, Tomokuni Abe, Tomonori Sonoki, Keisuke Miyauchi, Yoshihiro Katayama, Masao Fukuda   +7 more
openalex   +1 more source