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Demethylases Go Mental [PDF]

Molecular Cell, 2010
Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Dawson, Mark A., Bannister, Andrew J.
openaire   +2 more sources

FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms

International Journal of Molecular Sciences, 2022
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most abundant mRNA internal modification, which modulates several cellular processes including ...
S. Azzam, Habiba S. Alsafar, Abdulrahim A. Sajini   +2 more
semanticscholar   +1 more source

m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer

Molecular Therapy: Oncolytics, 2021
Non-small cell lung cancer (NSCLC) represents one of the primary causes of cancer-related mortality all over the world. Following our initial finding of the upregulated expression of E2F transcription factor-1 (E2F1) in the NSCLC-related microarray, this
Yanyun Wang, Man Li, Lin Zhang, Yitong Chen, Shoudan Zhang   +4 more
doaj   +1 more source

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

Molecular Cancer, 2022
Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but correlation between N6-methyladenosine (m6A) and GC metastasis was less ...
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Q. Luo, Sumin Wang, Y. Hou, Shiming Yang, Yufeng Xiao   +10 more
semanticscholar   +1 more source

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han, Zhen Liu, Yingying Xu, Xiangtian Liu, Dewei Wang, Fan Li, Yun Wang, Jianzhong Bi   +7 more
doaj   +1 more source

The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Molecular Cancer, 2022
N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, the expression of
Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He, Hailong Ma   +7 more
semanticscholar   +1 more source

Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels

Frontiers in Genetics, 2022
As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou   +8 more
doaj   +1 more source

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition

Nature Communications, 2023
The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T Roodman, F. X. Chen, Kaixiang Cao   +6 more
semanticscholar   +1 more source

Expressions of m6A methyltransferases and their associations with microR-21 and transforming growth factor-β1 in kidney of rats exposed to cadmium

环境与职业医学, 2022
BackgroundEnvironmental pollutants can affect N6-methyladenosine (m6A) level in the body, but the change of m6A level in kidney after being exposed to cadmium (Cd) and the molecular mechanism of renal injury need to be further studied.
Qian YANG, Yifan ZHANG, Zhichao HAN, Rujie LIU, Yuxing LI, Weitong SHEN, Yufen LIANG, Jiachen ZHANG, Shuangjing LI, Han ZHOU, Lijian LEI   +10 more
doaj   +1 more source

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

Journal of Experimental Medicine, 2021
Abdominal aortic aneurysms (AAAs) are a life-threatening disease characterized by macrophage infiltration contributing to pathological vascular remodeling.
Frank M. Davis, L. Tsoi, W. Melvin, A. denDekker, R. Wasikowski, Amrita D. Joshi, S. Wolf, A. Obi, A. Billi, X. Xing, C. Audu, B. Moore, S. Kunkel, A. Daugherty, Hong S. Lu, J. Gudjonsson, Katherine A. Gallagher   +16 more
semanticscholar   +1 more source