Results 21 to 30 of about 82,144 (300)

Expressions of m6A methyltransferases and their associations with microR-21 and transforming growth factor-β1 in kidney of rats exposed to cadmium

环境与职业医学, 2022
BackgroundEnvironmental pollutants can affect N6-methyladenosine (m6A) level in the body, but the change of m6A level in kidney after being exposed to cadmium (Cd) and the molecular mechanism of renal injury need to be further studied.
Qian YANG, Yifan ZHANG, Zhichao HAN, Rujie LIU, Yuxing LI, Weitong SHEN, Yufen LIANG, Jiachen ZHANG, Shuangjing LI, Han ZHOU, Lijian LEI   +10 more
doaj   +1 more source

Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
doaj   +1 more source

An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase

eLife, 2020
H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic ...
Gulzhan Raiymbek, Sojin An, Nidhi Khurana, Saarang Gopinath, Ajay Larkin, Saikat Biswas, Raymond C Trievel, Uhn-soo Cho, Kaushik Ragunathan   +8 more
doaj   +1 more source

JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]

, 2016
JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan, Han, Jihong, Li, Luyuan, Luo, Yunping, Ren, Guosheng, Shen, Long, Stupack, Dwayne G, Tan, Xiaoyue, Xiang, Rong, Xun, Jing, Zhang, Yan   +10 more
core   +1 more source

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
core   +2 more sources

Allyl Aryl Ether Cleavage by Blautia sp. MRG-PMF1 Cocorrinoid O-Demethylase

Microbiology Spectrum, 2022
Coabalamin-dependent O-demethylase in Blautia sp. strain MRG-PMF1 was found to catalyze the unprecedented allyl aryl ether cleavage reaction. To expand the potential biotechnological applications, the reaction mechanism of the allyl aryl ether C-O bond ...
Huynh Thi Ngoc Mi, Santipap Chaiyasarn, Bekir Engin Eser, Steven R. Susanto Tan, Supawadee Burapan, Jaehong Han   +5 more
doaj   +1 more source

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression

Balkan Medical Journal, 2022
Background: Diffuse large B-cell lymphoma is a type of B-cell non-Hodgkin lymphoma with a high incidence. About one-third of patients are resistant or eventually relapse.
YuYing Cui, Chao LV, Yu Wen, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wang   +6 more
doaj   +1 more source

A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

Frontiers in Pharmacology, 2022
Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological ...
Guan-Jun Yang, Guan-Jun Yang, Guan-Jun Yang, Yan-Jun Liu, Li-Jian Ding, Fan Tao, Ming-Hui Zhu, Zhen-Yuan Shi, Juan-Ming Wen, Meng-Yao Niu, Xiang Li, Zhan-Song Xu, Wan-Jia Qin, Chen-Jie Fei, Chen-Jie Fei, Chen-Jie Fei, Jiong Chen, Jiong Chen, Jiong Chen   +18 more
doaj   +1 more source

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources