Results 81 to 90 of about 765 (99)

Lysine demethylases and cancer

Pathology - Research and Practice
Epigenetic mechanisms are of pivotal importance in the normal development and maintenance of cell and tissue-specific gene expression patterns, and are fundamental to the genesis of cancer. One significant category of epigenetic modifications is histone methylation.
Tomas, Eckschlager, Ales, Vicha, Daniela, Frolikova   +2 more
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Opiate target site N-demethylase enzymes: Differences from the liver N-demethylase

Biochemical and Biophysical Research Communications, 1979
Abstract Mixtures of morphine-63H and morphine-N-14CH3 were incubated with rat brain subcellular fractions. Isotope ratio measurements served as the marker for identification, purification and quantitation of N-nor products which were shown to consist almost solely of N-normorphine.
E F, Hahn, B I, Norton, J, Fishman
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Recent Progress in Histone Demethylase Inhibitors

Journal of Medicinal Chemistry, 2016
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC
McAllister, Tom E.; England, Katherine S.; Hopkinson, Richard J.; Brennan, Paul E.; Kawamura, Akane; Schofield, Christopher J.   +6 more
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In Vitro Histone Demethylase Assays

2009
Histone methylation plays important roles in chromatin structure, transcription, and epigenetic state of the cell. Tremendous discoveries recently demonstrated that methylation mark is not static but is dynamically regulated by both histone methyltransferases and the histone demethylases.
Kenji, Kokura, Jia, Fang
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Histone Demethylases

Histone methylation is a dynamic process that contributes to the control of gene expression by influencing chromatin structure. Since their initial discovery 20 years ago, histone demethylases have been shown to play a critical role in histone methylation and thus developmental, physiological, and pathological processes.
Stephen C. Kales, Anton Simeonov
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In Vitro Histone Demethylase Assays

2015
Histone methylation plays pivotal roles in modulating chromatin structure and dynamics and in turn regulates genomic processes that require access to the DNA template. The methylation status at different sites is dynamically regulated by histone methyltransferases and demethylases. During the past decade, two classes of proteins have been characterized
Kenji, Kokura, Lidong, Sun, Jia, Fang
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Making a 6mA demethylase

Nature Chemical Biology, 2022
Sisi Li, Jiamu Du
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Lysine Demethylases Inhibitors

Journal of Medicinal Chemistry, 2011
Takayoshi, Suzuki, Naoki, Miyata
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Enzymatic Kraft lignin demethylation and fungal O-demethylases like vanillate-O-demethylase and syringate O-demethylase catalyzed catechol-Fe3+ complexation method

Journal of Microbiological Methods, 2018
The ability of enzymatic Kraft Lignin (KL) demethylation was determined using catechol and ferric ion coordination (catechol-Fe3+ complexes) by reduction of Fe3+ to Fe2+ and formation of mono, bis- and/or tris-catechol-Fe3+ complexes has been investigated to identify enzyme that can strip-off O-methyl groups from lignin such as O-demethylase. To detect
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The amazing demethylase

Nature, 1999
Howard Cedar, Gregory L. Verdine
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