Results 1 to 10 of about 37,089 (146)

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Nature Communications, 2022
Ischemic stroke can cause secondary myelin damage in the white matter distal to the primary injury site. The contribution of astrocytes during secondary demyelination and the underlying mechanisms are unclear.
Ting Wan, Wusheng Zhu, Ying Zhao, Xiaohao Zhang, Ruidong Ye, Meng Zuo, Pengfei Xu, Zhenqian Huang, Chunni Zhang, Yi Xie, Xinfeng Liu   +10 more
semanticscholar   +2 more sources

Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination

Journal of Neuroinflammation, 2023
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed in CNS diseases recently.
Yao Wang, Dilinuer Sadike, B. Huang, Ping Li, Qiao-qi Wu, Nanyang Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, M. Xie   +10 more
semanticscholar   +2 more sources

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Molecular Neurodegeneration, 2022
Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
M. Zirngibl, P. Assinck, Anastasia Sizov, A. Caprariello, Jason R. Plemel   +4 more
semanticscholar   +1 more source

Activated microglia drive demyelination via CSF1R signaling

Glia, 2021
Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS), a progressive auto‐immune demyelinating disorder.
Dave E Marzan, Valérie Brügger-Verdon, B. West, SA Liddelow, J. Samanta, J. Salzer   +5 more
semanticscholar   +1 more source

Association of CNS demyelination and COVID-19 infection: an updated systematic review

Journal of Neurology, 2021
Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The association between CNS demyelination and viral infection has long been documented, and this link ...
I. Ismail, S. Salama
semanticscholar   +1 more source

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, A. Haumont, Isadora Lenoël, P. Stys, S. David   +6 more
semanticscholar   +1 more source

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Science Advances, 2020
Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue. Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response to injury; however, the
Jason R. Plemel, Jason R. Plemel, J. A. Stratton, Nathan J. Michaels, Khalil S. Rawji, Eric L Zhang, S. Sinha, Charbel S. Baaklini, Yifei Dong, Madelene Ho, Kevin Thorburn, Timothy N. Friedman, Sana Jawad, Cláudia Silva, A. Caprariello, Vahid Hoghooghi, Julie Yue, A. Jaffer, Kelly V. Lee, B. Kerr, R. Midha, P. Stys, J. Biernaskie, V. Yong   +23 more
semanticscholar   +1 more source

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Nature Neuroscience, 2020
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new ...
Sarah A. Neely, Jill M Williamson, Anna Klingseisen, Lida Zoupi, J. Early, Anna C. Williams, D. Lyons   +6 more
semanticscholar   +1 more source

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Journal of Neurology Neurosurgery & Psychiatry, 2017
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
S. Ramanathan, S. Mohammad, E. Tantsis, Tina Nguyen, V. Merheb, V. Fung, O. White, S. Broadley, J. Lechner-Scott, S. Vucic, A. Henderson, M. Barnett, S. Reddel, F. Brilot, R. Dale   +14 more
semanticscholar   +1 more source

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Nature Communications, 2019
Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory diseases such as multiple sclerosis (MS) remyelination is often incomplete.
L. Kirby, Jing Jin, J. Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley J Strasburger, Leyla R Herbst, M. Alexis, J. Karnell, Todd S. Davidson, Ranjan Dutta, J. Goverman, D. Bergles, P. Calabresi   +14 more
semanticscholar   +1 more source