Results 1 to 10 of about 104,217 (332)

Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma? [PDF]

Frontiers in Aging Neuroscience, 2021
Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage.
Jingfei Xue, Yingting Zhu, Zhe Liu, Jicheng Lin, Yangjiani Li, Yiqing Li, Yehong Zhuo   +6 more
doaj   +2 more sources

Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology. [PDF]

PLoS Pathogens
As a central player in neuroinflammation, macrophages play multifaceted roles such as antigen presentation, phagocytosis, production of cytokines/chemokines, and growth/neurotrophic factors.
Ujjaldeep Jaggi, Satoshi Hirose, Shaohui Wang, Homayon Ghiasi   +3 more
doaj   +2 more sources

Demyelination-related pain: role of lysophosphatidic acid in satellite glial cell-neuron crosstalk. [PDF]

J Transl Med
Wang Y, Sun Q, Hanani M, Qu J, Guo X, Yang W, Shao T, Zheng S, Qiao S, Jia Y, Huang Y, Yang Y, Zhu H, Dong X, Zhou FQ, Guan Y, Song X, Chen Z.   +17 more
europepmc   +3 more sources

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination

Frontiers in Immunology, 2023
Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner.
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi   +8 more
doaj   +1 more source

Virus Demyelination [PDF]

Journal of Neurovirology, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
openaire   +4 more sources

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice. [PDF]

PLoS Pathogens, 2017
We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection
Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi   +6 more
doaj   +1 more source

Radiation Induced Demyelination in Cervical Spinal Cord of the Head and Neck Cancer Patients after Receiving Radiotherapy [PDF]

Journal of Biomedical Physics and Engineering, 2020
Background: Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N) cancer patients during radiotherapy.
H Goyal, N Singh, O P Gurjar, R K Tanwar
doaj   +1 more source

Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model

Journal of Integrative Neuroscience, 2023
Background: Multiple sclerosis (MS) is an autoimmune disease for which bone marrow mesenchymal stem cells (BM-MSCs) have become one of the most promising tools for treatment.
Chu Lei, Haowei Chen, Kangning Chen
doaj   +1 more source

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Neurobiology of Disease, 2022
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. We recently reported that the new antidepressant (R)-ketamine could ameliorate the disease progression in experimental autoimmune encephalomyelitis ...
Xingming Wang, Lijia Chang, Xiayun Wan, Yunfei Tan, Youge Qu, Jiajing Shan, Yong Yang, Li Ma, Kenji Hashimoto   +8 more
doaj   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj   +1 more source