Results 151 to 160 of about 70,292 (240)

Cerebellar tumefactive demyelination in MOGAD: a case report on diagnostic challenges and immunotherapeutic strategy. [PDF]

Front Immunol
Zheng X, Zhang J, Li D, Yuan B.
europepmc   +1 more source

MyD88 Deficiency Protects Mice From Experimental Autoimmune Encephalomyelitis by Influencing Both Dendritic Cells and T Cells

Immunology, Volume 177, Issue 4, Page 784-797, April 2026.
This study investigates the role of MyD88 in dendritic cells (DCs) and T cells during experimental autoimmune encephalomyelitis (EAE). We found that MyD88 is highly expressed in DCs and CD4+ T cells in people with multiple sclerosis, and its deficiency impairs DC maturation, reduces pro‐inflammatory cytokine production, weakens DC–T cell interactions ...
Wen Si, Gaochen Zhu, Qianling Jiang, Xin Ma, Guan Yang   +4 more
wiley   +1 more source

Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4. [PDF]

J Neuroinflammation
Nolt GL, Golden LR, Thorpe SP, Funnell JL, Stephens IO, Hernandez G, MacLean SM, Lucido CC, Brock CR, Pallerla AV, Adreon DR, Williams HC, Morganti JM, Johnson LA.   +13 more
europepmc   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS. [PDF]

Acta Neuropathol
Takai Y, Hametner S, Riedl C, Misu T, Takahashi T, Suzuki H, Chihara N, Watanabe M, Miyahara H, Yoshida M, Iwasaki Y, Suzuki T, Di Pauli F, Bramow S, Laureys G, Banwell B, Mariotto S, Fujihara K, Aoki M, Bradl M, Lassmann H, Höftberger R.   +21 more
europepmc   +1 more source

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients

Pain Practice, Volume 26, Issue 4, April 2026.
ABSTRACT Background Trigeminal neuralgia (TN) is a pain condition characterized by paroxysmal, electric shock‐like facial pain, affecting one or more areas of the branches. Approximately 33%–50% of patients require invasive treatment. Radiofrequency thermocoagulation (RFTC) is an established method for managing drug‐resistant and chronic TN. This study
Antti J. Luikku, Sara Matikka, Sami Heikkinen, Anssi Lipponen, Katja Luostarinen, Timo Koivisto, Ville Leinonen, Jukka Huttunen, Henna‐Kaisa Jyrkkänen   +8 more
wiley   +1 more source

<i>Aurkb</i> deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination. [PDF]

iScience
Yan W, Xiang D, Du L, Zhu D, Jia Q, Liu Y, Wang S, Liu L, Guan H, Zhao Y, Jiang G, Gao S, Wang H.   +12 more
europepmc   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Progressive Multifocal Leukoencephalopathy in a Patient With Miliary Tuberculosis: Differential Diagnosis From Tuberculoma. [PDF]

J Clin Neurol
Baek JG, Kwon HJ, Chae HM, Kwon DH.
europepmc   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 442-452, March 2026.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source