Results 171 to 180 of about 117,570 (300)

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway. [PDF]

Chin Med
Zhang L, Chen J, Yuen S, Wu M, Li W, Yan S, Shen J.   +6 more
europepmc   +1 more source

Glia Are Bussin’: How Single‐Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration

Glia, Volume 74, Issue 6, June 2026.
Neuroglia have been extensively profiled using single‐cell genomics, improving our understanding of their dynamics after spinal cord injury. A meta‐analysis of five single‐cell time‐course genomic studies reveals heterogeneity underscoring important challenges for interpretation.
Julio Mejia, Philip J. Horner
wiley   +1 more source

Leprosy neuropathy and demyelinating impairment: How should we interpret this neurophysiological pattern? [PDF]

PLoS One
Dos Santos DF, Carvalho IR, Borges IS, Alves PHSC, de Oliveira Cirino F, Antunes DE, Pereira RC, Gonçalves MVM, Bernardes Goulart IM.   +8 more
europepmc   +1 more source

Diffusion basis spectrum imaging provides insights into MS pathology [PDF]

, 2019
Cross, Anne H., George, Ajit, Naismith, Robert T., Perantie, Dana C., Song, Sheng-Kwei, Sun, Peng, Trinkaus, Kathryn, Ye, Zezhong   +7 more
core   +1 more source

Effects and Correction of Patient Bulk Motion in Cranial DENSE MRI

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3145-3160, June 2026.
ABSTRACT Purpose Applications of DENSE to measure cardiac driven brain tissue pulsations are highly sensitive to bulk patient motion due to the sub‐millimeter displacement encoding required, limiting its accuracy, reproducibility, and use in pediatric and aging populations.
Caroline A. Doctor, Leonardo A. Rivera‐Rivera, Laura B. Eisenmenger, Sterling C. Johnson, Kevin M. Johnson   +4 more
wiley   +1 more source

Reducing Variability in Deep Gray Matter QSM Using Differential ROI Referencing: A Phantom and In Vivo Evaluation

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
Differential ROI referencing in QSM reduces subject‐specific offsets and improves group‐discrimination sensitivity, enabling detection of PD‐related susceptibility differences (SN–PU). ABSTRACT Quantitative susceptibility mapping (QSM) measures the intrinsic magnetic susceptibility of tissues.
Tae Hyun Hwang, Gawon Lee, Myung Kyun Woo, Se‐Hong Oh   +3 more
wiley   +1 more source

Huazhuo Decoction Contributes to Immune Homeostasis and Attenuates Neuronal Inflammation and Demyelination in a Mouse Model of Multiple Sclerosis. [PDF]

J Inflamm Res
Wu JY, Zhang J, Xu S, Qian SY, Zha Z, Hu JL, Yang JL, Zhang FX, Zheng GQ.   +8 more
europepmc   +1 more source

Biallelic Nonsense Variants in NEFL May Cause a Non‐Length‐Dependent Neuropathy With Temporal Dispersion on Nerve Conduction Studies

Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Background and Aims Pathogenic variants in NEFL, the gene that encodes the light polypeptide subunit of neurofilaments, are an uncommon cause of autosomal recessive Charcot‐Marie‐Tooth (CMT) disease. In this study, we describe the clinical and electrophysiological features of two families with early‐onset CMT carrying nonsense variants in the ...
Marcus Vinícius Vieira da Silva Gomes, Pedro José Tomaselli, Wilson Marques Jr   +2 more
wiley   +1 more source

Subcortical microglial inflammation is uniquely linked to subpial cortical demyelination in multiple sclerosis. [PDF]

Neuroimage Clin
Thevakumaran R, Blinder S, Couch M, Kostikov A, Arnaoutelis R, Narayanan S, Rosa-Neto P, Arnold DL, Rudko DA.   +8 more
europepmc   +1 more source