Results 171 to 180 of about 94,021 (297)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Nonsystemic Vasculitic Neuropathy Presenting as Inflammatory Demyelinating Polyradiculoneuropathy. [PDF]

J Peripher Nerv Syst
Zhang T, Engelstad JK, Dyck PJB.
europepmc   +1 more source

Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to pollutant nanoparticles has been increasingly investigated due to concerns about their potential effects on placental function and pregnancy outcomes. Maternal inhalation of pollutant nanoparticles can result in a pro‐inflammatory response; particles can also translocate across the alveolus epithelial barrier
Katherine L. Bethell, Andrew C. Povey, Edward D. Johnstone, Peter T. Ruane   +3 more
wiley   +1 more source

Flunarizine prevents demyelination and neurological deficits in a cuprizone-induced mouse model of multiple sclerosis. [PDF]

Indian J Pharmacol
Venu G, Raj SSB.
europepmc   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses ». [PDF]

Rev Med Virol
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Plavina S, Malakovska D, Kalnina J, Trapina I, Leonova E, Habib M, Schifmann S, Paramonovs J, Sjakste N, Vassetzky Y, Drouet E, Paramonova N.   +11 more
europepmc   +2 more sources

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic Plasticity

Glia, Volume 74, Issue 12, December 2026.
Computational models illustrate how myelinating glia may shape the temporal integration of spikes upon a common postsynaptic target. Models show consequences for synaptic plasticity, neuronal excitability, and the fidelity of neural signals. ABSTRACT Myelin regulates neural signaling not only by enabling fast conduction but also by dynamically tuning ...
Daniel O'Sullivan, Aref Pariz, Daniel Trotter, Noor Z. Al Dahhan, Juliet K. Knowles, Paul W. Frankland, Donald Mabbott, Jérémie Lefebvre   +7 more
wiley   +1 more source

Effects of sphingosine-1-phosphate receptor modulators on remyelination in multiple sclerosis: evidence from <i>in vitro</i> experiments, animal models and human studies. [PDF]

Front Immunol
Ricigliano VAG.
europepmc   +1 more source

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex

Glia, Volume 74, Issue 12, December 2026.
We report that existing myelin allows neurons to remain plastic throughout life, while new myelin progressively stabilises synapses along the basal but not apical dendrites of layer V pyramidal neurons in the motor cortex. ABSTRACT Myelin has the capacity to affect synapse number or plasticity across the lifespan.
Renee E. Pepper, Kalina Makowiecki, Kimberley A. Pitman, Raphael Ricci, Angela L. Nicoli, Phuong Tram Nguyen, Catherine A. Blizzard, Ben Emery, Carlie L. Cullen, Kaylene M. Young   +9 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets. [PDF]

MedComm (2020)
Huang L, Cheng P, Liu G, Xiang Y, Hong Z, Le W.   +5 more
europepmc   +1 more source