Pharmacological Targeting of PI3K/Akt/mTOR and Wnt/GSK-3β Signaling in Oligodendrocyte Differentiation and Remyelination. [PDF]
Kim ME, Lee JS.
europepmc +1 more source
Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression
Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan +4 more
wiley +1 more source
Neurological fallout of hyperglycemia: A case report of a rare presentation of osmotic demyelination syndrome. [PDF]
Gupta R, Sachar C, Kaktyan P.
europepmc +1 more source
B-Cell Depletion as Evidence for Shared Neuroimmune Pathways in Combined Central and Peripheral Demyelination: A Case Report and Literature Review. [PDF]
Cucu LE +9 more
europepmc +1 more source
Case Report: Recurrent Guillain–Barré Syndrome in a 56‐Year‐Old Male
ABSTRACT Recurrent Guillain–Barré syndrome (GBS) is an uncommon variant of immune‐mediated polyradiculoneuropathy. We report a 56‐year‐old male who had two distinct episodes of acute inflammatory demyelinating neuropathy within the span of 3 months. The first episode presented with an episode of ascending paralysis and areflexia, with nerve conduction ...
Farah Sadiq +8 more
wiley +1 more source
Insights and challenges on animal models for progressive multiple sclerosis. [PDF]
Nalepa IF +5 more
europepmc +1 more source
ABSTRACT Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is an autoimmune disorder characterized by demyelination of the central nervous system. It can impact the optic nerves, spinal cord, brain parenchyma, and brainstem, resulting in various clinical presentations such as acute disseminated encephalomyelitis (ADEM), optic ...
Yuxian Shi +5 more
wiley +1 more source
Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice. [PDF]
Rokach M +3 more
europepmc +1 more source
ABSTRACT A 4‐year‐old boy presented with prolonged fever of unknown origin and systemic inflammation without early neurological signs. MRI revealed multifocal demyelination, and MOG antibodies were positive. He was diagnosed with ADEM and treated with steroids and IVIg, but relapsed twice, consistent with multiphasic disseminated encephalomyelitis ...
Pedro Pau
wiley +1 more source
Opioid Signaling in Multiple Sclerosis: Emerging Targets for Repair. [PDF]
Perlikowska R +3 more
europepmc +1 more source

