Results 221 to 230 of about 94,021 (297)

Lipid-coated mesoporous silica nanoparticles loaded with Thymoquinone as a novel treatment for experimental autoimmune encephalomyelitis in rats. [PDF]

BMC Pharmacol Toxicol
Fahmy HM, El-Feky AS, Ahmed MM, Mohamed AS, Shams-Eldin E, Abd El-Daim TM, Mustafa AB, Abd Alrahman MW, Mohammed FF, Fathy MM.   +9 more
europepmc   +1 more source

Volumetric and Intrastructural Characterization of the Substantia Nigra Using Optimized Synthetic MR Images Derived From Quantitative T1 Maps at 3 T

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
Automated segmentation using the NextBrain atlas and synthetic MRI effectively overcomes systematic age‐related biases observed in manual delineation of the substantia nigra. A novel qT1‐based synthetic contrast utilizing signal‐increased pseudo‐proton spin density (pPSD) provides improved intrastructural separation of nigral subregions (SNpc and SNpr)
Lukas von Erdmannsdorff, Lora Kovacheva, Dennis C. Thomas, Elke Hattingen, Ralf Deichmann, Christophe Théo Arendt   +5 more
wiley   +1 more source

From Neurovascular Compression to Neural Hyperexcitability: Integrating Microanatomy, Electrophysiology, and Computational Neuroscience to Understand Trigeminal Neuralgia and Hemifacial Spasm. [PDF]

Cells
Okuhata H, Aihara M, Oya S, Nagai R, Aizawa K.   +4 more
europepmc   +1 more source

In Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Short‐term cyclic partial reprogramming with Yamanaka factors protects aged mice from ischemic brain injury, preserving cognitive function, myelin integrity, and neuronal density, supporting partial reprogramming as a promising neuroprotective intervention in aging.
Paula R. Mallavibarrena, Gerardo Martín‐López, Jorge Rodríguez‐Morales, Jesús Ávila, Félix Hernández, María José Pérez‐Álvarez   +5 more
wiley   +1 more source

Therapeutic Window of AAV-SIRT1 Gene Therapy in Mouse Models of Optic Nerve Degeneration. [PDF]

Transl Vis Sci Technol
Chaqour B, Pham JC, Yue J, Dine K, Jin F, Ying GS, Bennett J, Shindler KS, Ross AG.   +8 more
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelination. [PDF]

PLoS One
De Herdt D, Lefevere E, Brouwers V, Hartvig L, Geeraerts E, Hsiao CC, Chen JQA, Pinto R, Duvey G, Burbidge S, Harmeier A, Knuesel I.   +11 more
europepmc   +1 more source

Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10670-10682, November 2026.
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk, Tina Okdahl, Marietta Kokla, Tommi Suvitaival, Gurjeet Kaur, Ismo M. Mattila, Simon M. Kienle, Christian Buhl, Knud Yderstræde, Troels S. Jensen, Peter Rossing, Flemming Pociot, Birgitte Brock, Cristina Legido‐Quigley, Páll Karlsson, Christian S. Hansen, Christina Brock, Joachim Størling, Karolina Sulek   +18 more
wiley   +1 more source