Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Narges Dastmalchi +3 more
wiley +1 more source
The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada +15 more
wiley +1 more source
Hemi-capsulo-rhombencephalic demyelination
Suresh Chandran C +2 more
doaj
Recombinant rat heat shock protein 70 (rrHSP70) may promote remyelination by regulating microglia/macrophages and oligodendrocytes in a toxin-induced demyelination animal model. [PDF]
Song J +17 more
europepmc +1 more source
A case of acute lithium encephalopathy associated with elevated myelin basic protein levels in cerebrospinal fluid [PDF]
Abstract Background Acute lithium intoxication can cause severe central nervous system (CNS) manifestations, sometimes leading to long‐term sequelae known as the syndrome of irreversible lithium‐effectuated neurotoxicity (SILENT). However, its underlying pathophysiology remains unclear.
Yokoyama T +3 more
europepmc +2 more sources
Mitochondrial Control of Myelination, Bioenergetics, Oxidative Stress, and the Pathogenesis of Optic Neuropathies. [PDF]
Sahibzada H, Malik R, Abu-Amero KK.
europepmc +1 more source
Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan +23 more
wiley +1 more source
Treatment of acute demyelinating encephalomyelitis associated with recent rickettsial infection. [PDF]
Dowe MC, Goyal T.
europepmc +1 more source
Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song +9 more
wiley +1 more source

