Results 41 to 50 of about 37,089 (146)

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj  

Central Pontine Demyelination: A Case Report

Nepal Journal of Neuroscience, 2016
Central Pontine Demyelination is a neurological disease caused by rapidly fl uctuating serum osmolality resulting in severe damage of the myelin sheath of nerve cells in the brainstem, more precisely in the area of pons. This condition is associated with
Manju Maharjan , Pranaya Shrestha, Avinash Chandra, Jemesh S Maharjan, Basant Pant   +4 more
doaj   +1 more source

IL-17A Mediates Demyelination by Activating A1 Astrocytes via SOCS3 During Angiostrongylus cantonensis Infection

Frontiers in Immunology, 2022
BackgroundDemyelinating disease of the central nervous system is one of the most common neurological diseases and effective treatment is still under in-depth research.
Zongpu Zhou, Tuo Lin, Zhen Liu, Qian Ding, Zhixuan Ma, Wanqi Li, Fukang Xie, Yue Lan, Ying Feng   +8 more
doaj   +1 more source

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

Annals of Neurology, 2018
Cortical gray matter (GM) pathology, involving demyelination and neurodegeneration, associated with meningeal inflammation, could be important in determining disability progression in multiple sclerosis (MS).
Ryan J. Bevan, Rhian Evans, Lauren Griffiths, Lewis M. Watkins, M. Rees, R. Magliozzi, I. Allen, G. McDonnell, Rachel Kee, M. Naughton, D. Fitzgerald, R. Reynolds, J. Neal, O. Howell   +13 more
semanticscholar   +1 more source

Strain differences in cuprizone induced demyelination

Cell & Bioscience, 2017
Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus, Renping Zhou   +6 more
doaj   +1 more source

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

eLife, 2016
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei, Feng Mei, K. Lehmann-Horn, Yun-An A. Shen, Kelsey A. Rankin, K. Stebbins, D. Lorrain, Kara Pekarek, Sharon A Sagan, L. Xiao, C. Teuscher, H. Büdingen, J. Wess, J. J. Lawrence, A. Green, S. Fancy, S. Zamvil, J. Chan   +17 more
semanticscholar   +1 more source

Clozapine administration enhanced functional recovery after cuprizone demyelination.

PLoS ONE, 2019
The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those ...
Nikki Templeton, Bronwyn Kivell, Amy McCaughey-Chapman, Bronwen Connor, Anne Camille La Flamme   +4 more
doaj   +1 more source

Optic nerve head: A gatekeeper for vitreous infectious insults?

Frontiers in Immunology, 2022
The axons of retinal ganglion cells (RGCs) pass through the optic nerve head (ONH) and form the optic nerve (ON). The ONH serves as an anatomical interface between the vitreous cavity and subarachnoid space.
Wenwen Lai, Wenwen Lai, Jie Huang, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Gezhi Xu, Xiaowei Wang, Fengfei Ding, Fengfei Ding   +13 more
doaj   +1 more source

LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination

EMBO Reports, 2017
The regulation of inflammation is pivotal for preventing the development or reoccurrence of multiple sclerosis (MS). A biased ratio of high‐M1 versus low‐M2 polarized microglia is a major pathological feature of MS.
Dingya Sun, Zhongwang Yu, Xue Fang, Mingdong Liu, Yingyan Pu, Qi Shao, Dan Wang, Xiaolin Zhao, Aijun Huang, Z. Xiang, Chao Zhao, R. Franklin, Li Cao, Cheng He   +13 more
semanticscholar   +1 more source

TREM2 sustains microglial expansion during aging and response to demyelination.

Journal of Clinical Investigation, 2015
Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as
P. L. Poliani, Yaming Wang, E. Fontana, M. Robinette, Y. Yamanishi, S. Gilfillan, M. Colonna   +6 more
semanticscholar   +1 more source