Results 61 to 70 of about 106,551 (295)

LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination

EMBO Reports, 2017
The regulation of inflammation is pivotal for preventing the development or reoccurrence of multiple sclerosis (MS). A biased ratio of high‐M1 versus low‐M2 polarized microglia is a major pathological feature of MS.
Dingya Sun, Zhongwang Yu, Xue Fang, Mingdong Liu, Yingyan Pu, Qi Shao, Dan Wang, Xiaolin Zhao, Aijun Huang, Z. Xiang, Chao Zhao, R. Franklin, Li Cao, Cheng He   +13 more
semanticscholar   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Dynamic Transcriptomic and Cellular Remodeling Underlie Cuprizone-Induced Demyelination and Endogenous Repair in the CNS

Antioxidants
Demyelination in the central nervous system (CNS) disrupts neuronal communication and promotes neurodegeneration. Despite the widespread use of cuprizone-induced demyelination models to study myelin injury and repair, the mechanisms underlying ...
Yantuanjin Ma, Tianyi Liu, Zhipeng Li, Wei Wei, Qiting Zhao, Shufen Wang   +5 more
doaj   +1 more source

LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model

Journal of Pharmacological Sciences, 2018
Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the alternation of pain-related genes/proteins expression and demyelination.
Ryoko Tsukahara, Shinji Yamamoto, Keisuke Yoshikawa, Mari Gotoh, Tamotsu Tsukahara, Hiroyuki Neyama, Satoshi Ishii, Noriyuki Akahoshi, Keisuke Yanagida, Hayakazu Sumida, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Kimiko Murakami-Murofushi, Hiroshi Ueda   +14 more
doaj   +1 more source

Incidence of osmotic demyelination syndrome in Sweden: A nationwide study

Acta Neurologica Scandinavica, 2019
To report the incidence rate of osmotic demyelination syndrome (ODS), associated risk factors, treatment, and long‐term outcomes in a nationwide cohort.
Hildur M Aegisdottir, Charith N. Cooray, K. Wirdefeldt, F. Piehl, O. Sveinsson   +4 more
semanticscholar   +1 more source

Biochemistry of Demyelination

Brain Pathology, 1996
The myelin sheath, a lipid‐rich multilamellar membrane of relative stability, both insulates and enhances conduction in nerve axons. A notable feature of myelin‐specific proteins, in particular myelin basic protein, is their susceptibility to prote‐olytic activity and their encephalitogenicity, which induces inflammatory demyelination in the CNS.
M L, Cuzner, W T, Norton
openaire   +2 more sources

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology.

PLoS Pathogens
As a central player in neuroinflammation, macrophages play multifaceted roles such as antigen presentation, phagocytosis, production of cytokines/chemokines, and growth/neurotrophic factors.
Ujjaldeep Jaggi, Satoshi Hirose, Shaohui Wang, Homayon Ghiasi   +3 more
doaj   +1 more source

Clozapine administration enhanced functional recovery after cuprizone demyelination.

PLoS ONE, 2019
The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those ...
Nikki Templeton, Bronwyn Kivell, Amy McCaughey-Chapman, Bronwen Connor, Anne Camille La Flamme   +4 more
doaj   +1 more source

Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases

Neural Regeneration Research, 2016
Induction of demyelination in the central nervous system (CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination.
Kidsadagon Pringproa, Anucha Sathanawongs, Chananthida Khamphilai, Sarocha Sukkarinprom, Apichart Oranratnachai   +4 more
doaj   +1 more source