Results 81 to 90 of about 94,021 (297)
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
, 2005 Destruction of myelindemyelinationoccurs in a variety of diverse inflammatory disorders. In some of these disorders, myelin breakdown is secondary to destruction of neurons: neuronolytic demyelination.
Barrett J. Katz, MD, MBA
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Demyelination models in the spinal cord
, 2011 Disruption of axonal conduction within the central nervous system has obvious, negative consequences on numerous functions, including the ability to execute movement successfully. One important cause of axonal conduction deficits is primary demyelination,
Paul A. Felts +9 more
core +1 more source
Advanced Science, EarlyView.A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong +17 more
wiley +1 more source
Is psychosis, at least in part, an immune-related dysmyelination disease?
Dialogues in Clinical Neuroscience & Mental Health, 2019 Epidemiological studies have borne out the association between psychotic disorders and autoimmune disease, while the immunogenetic contribution in psychosis is largely dominated by the major histocompatibility complex genetic diversity. On the other hand,
Orestis Giotakos
doaj +1 more source
Evaluation of type of segmental demyelination during episodes of neuritis.
, 2021 Evaluation of type of segmental demyelination during episodes of neuritis.
Márcia Jardim (11731388) +7 more
core +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
High resolution images MS lesion with moderate demyelination
, 2023 High resolution images of MS lesions with moderate ...
Strauß, J +26 more
core +1 more source
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Eye Movement Abnormalities in Osmotic Demyelination Syndrome
, 2009 Osmotic Demyelination Syndrome (ODS) is a term used for a demyelinating condition reported following rapid correction of hyponatremia. There are two subtypes depending on the location of the demyelination: central pontine myelinolysis (CPM) and ...
Kristen M. Hawthorne; Christopher Compton; Michael S. Vaphiades; Lanning B. Kline
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