Results 101 to 110 of about 94,021 (297)

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice

Stem Cell Reports, 2017
Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche.
Ilias Kazanis, Kimberley A. Evans, Evangelia Andreopoulou, Christina Dimitriou, Christos Koutsakis, Ragnhildur Thora Karadottir, Robin J.M. Franklin   +6 more
doaj   +1 more source

An ex-vivo multiple sclerosis model of inflammatory demyelination using hyperbranched polymer

, 2013
Multiple sclerosis (MS) is characterized by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to underlie the pathological changes,
W. McDermott, Kieran, S. Pandit, Abhay, Wang, Wenxin, Mathew, Asha, Reynolds, Richard, C. Collin, Estelle, M.P. Pakan, Janelle, Fitzgerald, Una, Pakan, Janelle M.P., McDermott, Kieran W., Pandit, Abhay S., Collin, Estelle C.   +11 more
core   +1 more source

Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination [PDF]

, 2000
Metabolic insult results in apoptosis and depletion of mature oligodendrocytes during demyelination. To examine the role of insulin-like growth factor-1 (IGF-1) during acute demyelination and remyelination in the adult CNS, we exposed transgenic mice ...
Matsushima, G. K., P. Ye, Suzuki, K., J. L. Mason, Mason, J. L., A. J. D'Ercole, G. K. Matsushima, Ye, P., D'Ercole, A. J., K. Suzuki   +9 more
core   +1 more source

Widespread demyelination in the cerebellar cortex in multiple sclerosis

, 2007
Neocortical demyelination in the forebrain has recently been identified as an important pathological feature of multiple sclerosis (MS). Here we describe that the cerebellar cortex is a major predilection site for demyelination, in particular in patients
Bauer, Jan, Kutzelnigg, Alexandra, Rauschka, Helmut, Laursen, Henning, Sorensen, Per Soelberg, Brueck, Wolfgang, Schmidbauer, Manfred, Lassmann, Hans, Lucchinetti, Claudia F., Stadelmann, Christine, Faber-Rod, Jens C.   +10 more
core   +1 more source

Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed, Supreet S. Randhawa, Jason H. Peragallo, Prabhumallikarjun Patil, Grace Gombolay, Varun Kannan   +5 more
wiley   +1 more source

Demyelination

, 2016
Abstract This chapter describes various clues to the diagnosis of multiple sclerosis (MS) based on the history, physical examination and investigation. Red flags that should alert the clinician to an alternative diagnosis are listed. Disorders that may present like MS and lead to erroneous diagnosis are discussed.
Christopher H. Hawkes, Kapil D. Sethi, Thomas R. Swift   +2 more
openaire   +2 more sources

Multiple sclerosis: a practical review for pathologists [PDF]

Journal of Pathology and Translational Medicine
Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple ...
Rachel A. Multz, Pouya Jamshidi, Jared T. Ahrendsen   +2 more
doaj   +1 more source

Demyelination Determinants in the S Gene of MHV

, 2001
Demyelination is the hallmark pathologic process of several viral-induced, and inflammatory, immune-mediated diseases of the central nervous system (Allen and Bradkin 1993).
Lavi, Ehud, Susan R. Weiss, Ehud Lavi, Sarma, Jayasri Das, Fu, Li, Weiss, Susan R., Li Fu, Jayasri Das Sarma   +7 more
core   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

Equine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan, Blythe Durbin‐Johnson, Kevin Woolard, Andrew D. Miller, Carrie J. Finno   +4 more
wiley   +1 more source

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.

, 2015
Conventional MRI is frequently used during the diagnosis of multiple sclerosis but provides only little additional pathological information. Proton MRS (1H-MRS), however, provides biochemical information on the lesion pathology by visualization of a ...
Santermans, Eva, Van Der Linden, Anne-Marie, Ponsaerts, Peter, Van der Linden, Annemie, Verhoye, Marleen, Hens, Niel, Praet, Jelle, Kara, Firat, Berneman, Zwi, Orije, Jasmien, Daans, Jasmijn, Guglielmetti, Caroline   +11 more
core   +1 more source