Results 101 to 110 of about 106,551 (295)

Transient auditory nerve demyelination as a new mechanism for hidden hearing loss

Nature Communications, 2017
Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests.
Guoqiang Wan, G. Corfas
semanticscholar   +1 more source

Demyelination

, 2016
Abstract This chapter describes various clues to the diagnosis of multiple sclerosis (MS) based on the history, physical examination and investigation. Red flags that should alert the clinician to an alternative diagnosis are listed. Disorders that may present like MS and lead to erroneous diagnosis are discussed.
Christopher H. Hawkes, Kapil D. Sethi, Thomas R. Swift   +2 more
openaire   +2 more sources

Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex

Neuropathology and Applied Neurobiology, 2018
Indices of brain volume [grey matter, white matter (WM), lesions] are being used as outcomes in clinical trials of patients with multiple sclerosis (MS).
D. Carassiti, Daniel R. Altmann, N. Petrova, B. Pakkenberg, F. Scaravilli, K. Schmierer, K. Schmierer   +6 more
semanticscholar   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

Equine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan, Blythe Durbin‐Johnson, Kevin Woolard, Andrew D. Miller, Carrie J. Finno   +4 more
wiley   +1 more source

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Acta Neuropathologica, 2017
Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter damage are only incompletely understood.
Nielsen Lagumersindez-Denis, Claudia Wrzos, M. Mack, A. Winkler, F. van der Meer, M. Reinert, Heiko Hollasch, A. Flach, H. Brühl, E. Cullen, C. Schlumbohm, E. Fuchs, C. Linington, A. Barrantes-Freer, I. Metz, C. Wegner, D. Liebetanz, M. Prinz, W. Brück, C. Stadelmann, S. Nessler   +20 more
semanticscholar   +1 more source

A case report: Diagnosis and treatment of idiopathic hypertrophic pachymeningitis

Ibrain, Volume 11, Issue 1, Page 112-116, Spring 2025.
We reported a case of idiopathic hypertrophic dura meningitis diagnosed in our hospital. The patient repeatedly suffered from headaches, followed by blurred vision in the right eye. During this period, multiple sclerosis was considered for diagnosis, and it improved after hormone treatment.
Zhong Luo, Piao Cao, Jing‐Qing Xu, Rong Yan, Jian Wang, Tao Liang, Ya Chen, Zu‐Cai Xu   +7 more
wiley   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating From Axonal Polyneuropathies

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Differentiating demyelinating from axonal polyneuropathies helps for accurate diagnosis and treatment. However, the current clinical tools lack sensitivity to confirm demyelination in peripheral nerves, particularly for proximal nerves.
Jesus E. Fajardo, Vivian B. Truong, Yang Xuan, Sara E. Benitez, Mary L. Vo, Bo Hu, Richard D. Dortch, Jun Li, Yongsheng Chen   +8 more
wiley   +1 more source