Results 121 to 130 of about 117,570 (300)

Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis

open access: yesBrain Sciences
Multiple sclerosis (MS) is an autoimmune disease that damages the myelin sheath around the central nervous system axons, leading to neurological dysfunction.
Bethany Y. A. Hollingworth   +3 more
doaj   +1 more source

Effects of intermittent fasting on experimental autoimune encephalomyelitis in C57BL/6 mice [PDF]

open access: yes, 2016
Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course.
Alizadeh, A.   +5 more
core   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

open access: yesiNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu   +2 more
wiley   +1 more source

INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW

open access: yesАвтоматизация технологических и бизнес-процессов
. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS).
Chathurika AGJ, Hettige B, Marikar FMMT
doaj   +1 more source

AI‐Powered Gradient Echo Plural Contrast Imaging (AI‐GEPCI)—A Comprehensive Neurological Protocol From a Single MRI Scan

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI is essential for diagnosing and monitoring neurological diseases. Conventional protocols require multiple sequences to obtain complementary contrasts, increasing scan time, cost, and tolerability. Generating multiple contrasts from a single acquisition may streamline workflow while maintaining clinical utility.
Jeramy Lewis   +8 more
wiley   +1 more source

Value of 2‐Dimensional Shear‐Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy

open access: yesJournal of Ultrasound in Medicine, EarlyView.
Objectives The morphological alterations of the tibial nerve in patients with diabetes mellitus, both with and without diabetic peripheral neuropathy (DPN), are challenging to differentiate using B‐mode ultrasound. In this study, we assessed the stiffness changes of the tibial nerve by 2‐dimensional shear‐wave elastography (2D‐SWE). Methods We gathered
Jiafan Li   +4 more
wiley   +1 more source

Demyelination

open access: yes, 2007
Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease that affects all ages, except children less than 2 years. It occurs during the course of various infections, particularly the acute exanthematous diseases of childhood (measles, rubella, chickenpox, and smallpox immunization), other common viral infections (i.e., Epstein-Barr virus,
openaire   +1 more source

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng   +6 more
wiley   +1 more source

Personalized Treatment of Patients With Multiple Sclerosis: A Case Report and Literature Review

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT Managing multiple sclerosis (MS) with a highly active disease course presents significant challenges, particularly regarding the timing of therapeutic escalation and the preservation of brain volume. We present a personalized management strategy for a 36‐year‐old male with relapsing‐remitting MS (RRMS) who experienced initial misdiagnosis ...
Fengjun Wang   +3 more
wiley   +1 more source

The Spectrum of Abnormal Tongue Movements: Review of Phenomenology, Etiology, and Differential Diagnosis

open access: yesMovement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan   +4 more
wiley   +1 more source

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