Results 51 to 60 of about 31,253 (298)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Current-induced dendritic magnetic instability in superconducting MgB2 films
, 2002 Magneto-optical imaging reveals that in superconducting films of MgB2 a transport current creates avalanche-like flux dynamics where highly branching dendritic penetration patterns are formed.
Bobyl, A. V. +6 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
BatteriesLithium metal batteries offer high energy density but are challenged by dendrite growth, which can lead to short circuits and battery failure. Multiple models with varying degrees of accuracy and computational cost have been developed to understand and ...
Rok Peklar, Urša Mikac, Igor Serša
doaj +1 more source
Neuromodulatory control of localized dendritic spiking in critical period cortex. [PDF]
, 2019 Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing1. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age
Ringach, Dario L +2 more
core
Nicotine has suppressive effects on dendritic cell function
Immunology, 2003 Cigarette smoking is a major health hazard which increases the risk of cancer, particularly lung cancer, as well as cardiovascular and respiratory disease. Damage to the immune response is considered to underlie many problems provoked by smoking, and alteration in responsiveness of smokers' leukocytes has been recorded.1 For example, T cells ...
openaire +3 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
eLife, 2020 During prolonged nutrient restriction, developing animals redistribute vital nutrients to favor brain growth at the expense of other organs. In Drosophila, such brain sparing relies on a glia-derived growth factor to sustain proliferation of neural stem ...
Amy R Poe +6 more
doaj +1 more source
, 2005 From the magneto optics images (MOI), the dendritic magnetic avalanche is known to appear dominantly for thin films of the newly discovered MgB$_2$. To clarify the origin of this phenomenon, we studied in detail the MOI of carbon-free MgB$_2$ thin films ...
A. A. F. Olsen +8 more
core +1 more source
Neurons and circuits for odor processing in the piriform cortex [PDF]
, 2013 Increased understanding of the early stages of olfaction has lead to a renewed interest in the higher brain regions responsible for forming unified ‘odor images’ from the chemical components detected by the nose.
Bekkers, John MacDonald +1 more
core +1 more source