Results 51 to 60 of about 591,136 (270)

The role of dendritic spines in epileptogenesis

Frontiers in Cellular Neuroscience, 2023
Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy.
Gary Jean, Joseph Carton, Kaleem Haq, Alberto E. Musto, Alberto E. Musto   +4 more
doaj   +1 more source

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. [PDF]

, 2017
Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Achiro, Jennifer M, Choi, Jinkuk, Gao, Jie, Kim, Sangmok, Li, Sandy, Marosi, Mate, Martin, Kelsey C, Otis, Klara, Portera-Cailliau, Carlos, Tontonoz, Peter   +9 more
core   +3 more sources

CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNFα

Nature Medicine, 2017
Impaired learning and cognitive function often occurs during systemic infection or inflammation. Although activation of the innate immune system has been linked to the behavioral and cognitive effects that are associated with infection, the underlying ...
J. M. Garré, H. M. Silva, J. Lafaille, Guang Yang   +3 more
semanticscholar   +1 more source

Lipid dynamics at dendritic spines [PDF]

Frontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine plasticity.
Dotti, Carlos Gerardo, Esteban, Jose Antonio, Ledesma, María Dolores   +2 more
openaire   +4 more sources

Low-intensity transcranial ultrasound stimulation improves memory in vascular dementia by enhancing neuronal activity and promoting spine formation

NeuroImage
Memory is closely associated with neuronal activity and dendritic spine formation. Low-intensity transcranial ultrasound stimulation (TUS) improves the memory of individuals with vascular dementia (VD).
Jiamin Pei, Cong Zhang, Xiao Zhang, Zhe Zhao, Xiangjian Zhang, Yi Yuan   +5 more
doaj   +1 more source

Dendritic Spines in the Spinal Cord: Live Action Pain

Neuroscience Insights, 2020
Dendritic spines are microscopic protrusions on neurons that house the postsynaptic machinery necessary for neurotransmission between neurons. As such, dendritic spine structure is intimately linked with synaptic function.
Curtis A Benson, Marike L Reimer, Andrew M Tan   +2 more
doaj   +1 more source

A Dynamin-3 Spliced Variant Modulates the Actin/Cortactin-Dependent Morphogenesis of Dendritic Spines [PDF]

, 2005
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its function
Chen, Jing, Gray, Noah W., Kruchten, Anne E., McNiven, Mark A.   +3 more
core   +2 more sources

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium

bioRxiv, 2018
Dendritic spines are small subcompartments protruding from the dendrites of neurons that are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes. While it is known that these
M. Bell, Tomas M. Bartol, T. Sejnowski, P. Rangamani   +3 more
semanticscholar   +1 more source

Dopaminergic signaling in dendritic spines [PDF]

Biochemical Pharmacology, 2008
Dopamine regulates movement, motivation, reward, and learning and is implicated in numerous neuropsychiatric and neurological disorders. The action of dopamine is mediated by a family of seven-transmembrane G protein-coupled receptors encoded by at least five dopamine receptor genes (D1, D2, D3, D4, and D5), some of which are major molecular targets ...
Wei-Dong, Yao, Roger D, Spealman, Jingping, Zhang   +2 more
openaire   +2 more sources

Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior

Cell Reports, 2019
Summary: During development, the precise implementation of molecular programs is a key determinant of proper dendritic development. Here, we demonstrate that canonical Wnt signaling is active in dendritic bundle-forming layer II pyramidal neurons of the ...
Beatrice Viale, Lin Song, Volodymyr Petrenko, Anne-Laure Wenger Combremont, Alessandro Contestabile, Riccardo Bocchi, Patrick Salmon, Alan Carleton, Lijia An, Laszlo Vutskits, Jozsef Zoltan Kiss   +10 more
doaj   +1 more source