Spinal cord motor neuron plasticity accompanies second‐degree burn injury and chronic pain
Physiological Reports, 2019 Burn injuries and associated complications present a major public health challenge. Many burn patients develop clinically intractable complications, including pain and other sensory disorders. Recent evidence has shown that dendritic spine neuropathology
Siraj Patwa +7 more
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Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
Scientific Reports, 2020 Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to ...
Megan E. Fox +3 more
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Image informatics strategies for deciphering neuronal network connectivity [PDF]
, 2016 Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani +99 more
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Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. [PDF]
PLoS ONE, 2014 General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction.
Jimcy Platholi +3 more
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PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
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Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]
, 2019 Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom +3 more
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The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
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Dendritic spine alterations in schizophrenia [PDF]
Neuroscience Letters, 2015 Schizophrenia is a chronic illness affecting approximately 0.5-1% of the world's population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal ...
Caitlin E, Moyer +2 more
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Neural Plasticity, 2016 Dendritic spines are the location of excitatory synapses in the mammalian nervous system and are neuron-specific subcellular structures essential for neural circuitry and function. Dendritic spine morphology is determined by the F-actin cytoskeleton.
Hsiao-Tang Hu +3 more
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Nerve Conduction Through Dendrites via Proton Hopping [PDF]
, 2017 Background: In our previous studies of nerve conduction conducted by proton hopping, we have considered the axon, soma, synapse and the nodes of Ranvier.
Kier, Lemont B.
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