Results 51 to 60 of about 87,585 (230)
Dendritic spine pathology in schizophrenia [PDF]
Neuroscience, 2013 Schizophrenia is a neurodevelopmental disorder whose clinical features include impairments in perception, cognition and motivation. These impairments reflect alterations in neuronal circuitry within and across multiple brain regions that are due, at least in part, to deficits in dendritic spines, the site of most excitatory synaptic connections ...
David A. Lewis, Jill R. Glausier
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Cell Reports, 2019 Summary: During development, the precise implementation of molecular programs is a key determinant of proper dendritic development. Here, we demonstrate that canonical Wnt signaling is active in dendritic bundle-forming layer II pyramidal neurons of the ...
Beatrice Viale +10 more
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Three-dimensional spatial modeling of spines along dendritic networks in human cortical pyramidal neurons. [PDF]
PLoS ONE, 2017 We modeled spine distribution along the dendritic networks of pyramidal neurons in both basal and apical dendrites. To do this, we applied network spatial analysis because spines can only lie on the dendritic shaft.
Laura Anton-Sanchez +5 more
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Dendritic Spines and Distributed Circuits [PDF]
Neuron, 2011 Dendritic spines receive most excitatory connections in pyramidal cells and many other principal neurons. But why do neurons use spines, when they could accommodate excitatory contacts directly on their dendritic shafts? One suggestion is that spines serve to connect with passing axons, thus increasing the connectivity of the dendrites.
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EphA7 isoforms differentially regulate cortical dendrite development.
PLoS ONE, 2020 The shape of a neuron facilitates its functionality within neural circuits. Dendrites integrate incoming signals from axons, receiving excitatory input onto small protrusions called dendritic spines.
Carrie E Leonard +4 more
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The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. [PDF]
, 2017 Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Achiro, Jennifer M +9 more
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MARCKS for Maintenance in Dendritic Spines [PDF]
Neuron, 2005 Synapses in the brain must maintain a balance between learning-related plasticity and the stability necessary for reliable function. In this issue of Neuron, Calabrese and Halpain describe cell-transfection experiments implicating MARCKS, a protein that binds to both the cell surface and actin cytoskeleton, in the maintenance of dendritic spines.
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Changing the size of dendritic spines
eLife, 2023 Interactions between an enzyme kinase, an ion channel and cytoskeletal proteins maintain the structure of synapses involved in memory formation.
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Electrical Advantages of Dendritic Spines
PLoS ONE, 2012 Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the absence of spines, the amplitudes and kinetics of excitatory postsynaptic potentials (EPSPs) at the site of synaptic input are highly variable and depend on dendritic location.
Gulledge, Allan T. +2 more
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Spinal cord motor neuron plasticity accompanies second‐degree burn injury and chronic pain
Physiological Reports, 2019 Burn injuries and associated complications present a major public health challenge. Many burn patients develop clinically intractable complications, including pain and other sensory disorders. Recent evidence has shown that dendritic spine neuropathology
Siraj Patwa +7 more
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