Results 71 to 80 of about 87,585 (230)
The role of drebrin in dendritic spines
Molecular and Cellular Neuroscience, 2017 Dendritic spines form typical excitatory synapses in the brain and their shapes vary depending on synaptic inputs. It has been suggested that the morphological changes of dendritic spines play an important role in synaptic plasticity. Dendritic spines contain a high concentration of actin, which has a central role in supporting cell motility, and ...
Noriko Koganezawa +3 more
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Dendritic spine alterations in schizophrenia [PDF]
Neuroscience Letters, 2015 Schizophrenia is a chronic illness affecting approximately 0.5-1% of the world's population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal ...
Micah A. Shelton +3 more
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PLoS ONE, 2018 Synaptic plasticity, the cellular basis for learning and memory, is mediated by a complex biochemical network of signaling proteins. These proteins are compartmentalized in dendritic spines, the tiny, bulbous, post-synaptic structures found on neuronal ...
Michael S Smirnov +2 more
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Structural plasticity of dendritic spines [PDF]
Current Opinion in Neurobiology, 2012 Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling.
Miquel Bosch, Yasunori Hayashi
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Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in
Journal of Experimental Neuroscience, 2018 The development of the nervous system requires precise outgrowth, extension, and wiring of both axons and dendrites to generate properly functioning neural circuits.
Devyn Oliver +2 more
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Barriers in the Brain: Resolving Dendritic Spine Morphology and Compartmentalization
Frontiers in Neuroanatomy, 2014 Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the central nervous system. The head of the spine is connected to the dendritic shaft by a 50-400 nm thin membrane tube, called the spine neck, which has ...
Max eAdrian +5 more
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The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density
Translational Psychiatry, 2022 The missense variant rs13107325 (C/T, p.Ala391Thr) in SLC39A8 consistently showed robust association with schizophrenia in recent genome-wide association studies (GWASs), suggesting the potential pathogenicity of this non-synonymous risk variant ...
Shiwu Li +15 more
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Calcium Signaling in Dendritic Spines [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Calcium (Ca(2+)) is a ubiquitous signaling molecule that accumulates in the cytoplasm in response to diverse classes of stimuli and, in turn, regulates many aspects of cell function. In neurons, Ca(2+) influx in response to action potentials or synaptic stimulation triggers neurotransmitter release, modulates ion channels, induces synaptic plasticity ...
Bernardo L. Sabatini, Michael J. Higley
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Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference. [PDF]
, 2013 Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery.
Athilingam, Jegath +3 more
core
Active elastohydrodynamics of vesicles in narrow, blind constrictions [PDF]
, 2017 Fluid-resistance limited transport of vesicles through narrow constrictions is a recurring theme in many biological and engineering applications. Inspired by the motor-driven movement of soft membrane-bound vesicles into closed neuronal dendritic spines,
Fai, Thomas G. +4 more
core +4 more sources