Results 71 to 80 of about 94,485 (200)

Barriers in the Brain: Resolving Dendritic Spine Morphology and Compartmentalization

Frontiers in Neuroanatomy, 2014
Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the central nervous system. The head of the spine is connected to the dendritic shaft by a 50-400 nm thin membrane tube, called the spine neck, which has ...
Max eAdrian, Remy eKusters, Corette J Wierenga, Cornelis eStorm, Casper C Hoogenraad, Lukas C Kapitein   +5 more
doaj   +1 more source

The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density

Translational Psychiatry, 2022
The missense variant rs13107325 (C/T, p.Ala391Thr) in SLC39A8 consistently showed robust association with schizophrenia in recent genome-wide association studies (GWASs), suggesting the potential pathogenicity of this non-synonymous risk variant ...
Shiwu Li, Changguo Ma, Yifan Li, Rui Chen, Yixing Liu, Li Pear Wan, Qiuxia Xiong, Chuang Wang, Yongxia Huo, Xinglun Dang, Yongfeng Yang, Luxian Lv, Xi Chen, Nengyin Sheng, Wenqiang Li, Xiong-Jian Luo   +15 more
doaj   +1 more source

MicroRNA-9 controls dendritic development by targeting REST [PDF]

, 2014
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain.
Akerblom, Akerblom, Ameres, Andres, Aoki, Bak, Ballas, Ballas, Barnes, Bartel, Bonev, Bonhoeffer, Bushati, Caceres, Care, Chen, Chen, Coolen, Coolen, Dajas-Bailador, Delaloy, Dieni, Dotti, Ebert, Edbauer, Feng, Fiore, Gao, Gentner, Giraldez, Goslin, Han, Hand, Haramati, Hering, Hitz, Horch, Jan, Jiang, Jorgensen, Kawabe, Kawauchi, Kluiver, Koch, Kolb, Krichevsky, Kruger, Kuwabara, Laemmli, Lagos-Quintana, Lagos-Quintana, Leucht, Liu, Liu, Liu, London, Loya, Luxenhofer, Ma, Madisen, Magill, Mumm, Nadeau, Olena, Ooi, Otaegi, Packer, Parrish, Parrish, Pathania, Polleux, Qin, Rajan, Refojo, Rodriguez, Saito, Sauvageau, Schoenherr, Schratt, Senyuk, Shibata, Simó, Soriano, Spruston, Sudhof, Takemoto-Kimura, Tronche, Urbanska, Wayman, Whitford, Witkos, Wong, Yamamoto, Yao, Yoo, Zhao   +95 more
core   +1 more source

Structural plasticity of dendritic spines [PDF]

Current Opinion in Neurobiology, 2012
Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling.
Miquel, Bosch, Yasunori, Hayashi
openaire   +2 more sources

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

Neurobiology of Disease, 2009
Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models ...
Tara L. Spires-Jones, Matthew L. Mielke, Anete Rozkalne, Melanie Meyer-Luehmann, Alix de Calignon, Brian J. Bacskai, Dale Schenk, Bradley T. Hyman   +7 more
doaj   +1 more source

Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus.

PLoS Biology, 2023
Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity.
Hsiao-Tang Hu, Yung-Jui Lin, Ueh-Ting Tim Wang, Sue-Ping Lee, Yae-Huei Liou, Bi-Chang Chen, Yi-Ping Hsueh   +6 more
doaj   +1 more source

Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability [PDF]

, 2017
Oligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophnl affects neuronal development is only partly understood.
Allegra, M, Azzimondi, S, Billuart, P, Busti, I, Caleo, M, Canossa, M, Spalletti, C, Vignoli, B   +7 more
core   +1 more source

Microtubules in Dendritic Spine Development [PDF]

The Journal of Neuroscience, 2008
It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation.
Jiaping, Gu, Bonnie L, Firestein, James Q, Zheng   +2 more
openaire   +2 more sources

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL

Biological Research, 2023
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang   +10 more
doaj   +1 more source

A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]

, 2018
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H, Dumdie, J, Espinoza, JL, Gecz, J, Huang, L, Jolly, LA, Jones, SH, Kim, H, Lou, C-H, Phan, MH, Roberts, AJ, Shum, EY, Skarbrevik, DM, Swerdlow, NR, Wilkinson, MF   +14 more
core   +1 more source