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Microelastic mapping of the rat dentate gyrus [PDF]
Royal Society Open Science, 2016 The lineage commitment of many cultured stem cells, including adult neural stem cells (NSCs), is strongly sensitive to the stiffness of the underlying extracellular matrix. However, it remains unclear how well the stiffness ranges explored in culture align with the microscale stiffness values stem cells actually encounter within their ...
Tomás Luque +3 more
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PLoS Biology, 2010 The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories.
Alfonso Lavado +4 more
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Scientific Reports, 2017 Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus.
Serena Dillon +9 more
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Nature Communications, 2017 Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant
S. A. Raza +12 more
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Brain injury impairs dentate gyrus inhibitory efficacy
Neurobiology of Disease, 2007 Every 23 s, a person sustains a traumatic brain injury in the United States leaving many patients with substantial cognitive impairment and epilepsy.
David P. Bonislawski +2 more
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Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis
Journal of Developmental Biology, 2020 We have previously described hypomorphic reelin (Reln) mutant mice, RelnCTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice.
Seungshin Ha +4 more
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Synaptic Plasticity in the Human Dentate Gyrus [PDF]
The Journal of Neuroscience, 2000 Activity-dependent plasticity is a fundamental feature of most CNS synapses and is thought to be a synaptic correlate of memory in rodents. In humans, NMDA receptors have been linked to verbal memory processes, but it is unclear whether NMDA receptor-dependent synaptic plasticity can be recruited for information storage in the human CNS.
H, Beck +4 more
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Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. [PDF]
PLoS ONE, 2015 The dentate gyrus is considered to function as an inhibitory gate limiting excitatory input to the hippocampus. Following status epilepticus (SE), this gating function is reduced and granule cells become hyper-excitable.
Sean P Flynn +4 more
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YTHDF2 in dentate gyrus is the m 6 A reader mediating m 6 A modification in hippocampus-dependent learning and memory [PDF]
, 2022 Mengru Zhuang +10 more
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Endocannabinoids in the dentate gyrus [PDF]
, 2007 Recent years have produced rapid and enormous growth in our understanding of endocannabinoid-mediated signaling in the CNS. While much of the recent progress has focused on other areas of the brain, a significant body of evidence has developed that indicates the presence of a robust system for endocannabinoid-mediated signaling in the dentate gyrus ...
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