Dentate gyrus is needed for memory retrieval. [PDF]
Mol PsychiatryAbstractThe hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- and optogenetic-mediated hyperpolarization led to opposing conclusions about DG’s role in memory retrieval.
Carretero-Guillén A +10 more
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Neurogenesis in the dentate gyrus: carrying the message or dictating the tone
Frontiers in Neuroscience, 2013 The dentate gyrus is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas.
Laura A Ewell, Jill K Leutgeb
exaly +3 more sources
p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise
Frontiers in Cellular Neuroscience, 2019 In the neurogenic niches—the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles—stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus ...
Raffaella Scardigli +2 more
exaly +3 more sources
MGluR5 mediates the interaction between late-LTP, network activity, and learning. [PDF]
PLoS ONE, 2008 Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena.
Arthur Bikbaev +5 more
doaj +1 more source
Enigmas of the Dentate Gyrus [PDF]
Neuron, 2007 We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate differentiation between environments ...
Edvard I. Moser, Jill K. Leutgeb
openaire +3 more sources
Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat. [PDF]
PLoS ONE, 2011 The dentate gyrus is a site of continued neurogenesis in the adult brain. The CA3 region of the hippocampus is the major projection area from the dentate gyrus. CA3 sends reciprocal projections back to the dentate gyrus.
Jian Xin Liu +2 more
doaj +1 more source
Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. [PDF]
PLoS ONE, 2009 Physical exercise has been shown to increase adult neurogenesis in the dentate gyrus and enhances synaptic plasticity. The antiapoptotic kinase, Akt has also been shown to be phosphorylated following voluntary exercise; however, it remains unknown ...
Elodie Bruel-Jungerman +5 more
doaj +1 more source
Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2 [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Prostaglandin E2 E-prostanoid 2 receptor (PGE2 EP2), downstream of cyclooxygenase-2 (COX-2), plays an important role in inflammatory responses, but there are some reports about synaptic functions of COX-2 and PGE2 EP2 in the hippocampus ...
Hyo Young Jung +10 more
doaj +1 more source
Synchronous activity patterns in the dentate gyrus during immobility
eLife, 2021 The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also
Martin Pofahl +10 more
doaj +1 more source
Early natural stimulation through environmental enrichment accelerates neuronal development in the mouse dentate gyrus. [PDF]
PLoS ONE, 2012 The dentate gyrus is the primary afferent into the hippocampal formation, with important functions in learning and memory. Granule cells, the principle neuronal type in the dentate gyrus, are mostly formed postnatally, in a process that continues into ...
Na Liu, Shan He, Xiang Yu
doaj +1 more source