Results 1 to 10 of about 63,053 (291)

MGluR5 mediates the interaction between late-LTP, network activity, and learning. [PDF]

PLoS ONE, 2008
Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena.
Arthur Bikbaev, Sergey Neyman, Richard Teke Ngomba, P Jeffrey Conn, Ferdinando Nicoletti, Denise Manahan-Vaughan   +5 more
doaj   +1 more source

Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat. [PDF]

PLoS ONE, 2011
The dentate gyrus is a site of continued neurogenesis in the adult brain. The CA3 region of the hippocampus is the major projection area from the dentate gyrus. CA3 sends reciprocal projections back to the dentate gyrus.
Jian Xin Liu, Scarlett B Pinnock, Joe Herbert   +2 more
doaj   +1 more source

Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. [PDF]

PLoS ONE, 2009
Physical exercise has been shown to increase adult neurogenesis in the dentate gyrus and enhances synaptic plasticity. The antiapoptotic kinase, Akt has also been shown to be phosphorylated following voluntary exercise; however, it remains unknown ...
Elodie Bruel-Jungerman, Alexandra Veyrac, Franck Dufour, Jennifer Horwood, Serge Laroche, Sabrina Davis   +5 more
doaj   +1 more source

Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2 [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Prostaglandin E2 E-prostanoid 2 receptor (PGE2 EP2), downstream of cyclooxygenase-2 (COX-2), plays an important role in inflammatory responses, but there are some reports about synaptic functions of COX-2 and PGE2 EP2 in the hippocampus ...
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Sung Min Nam, Sun Shin Yi, Hyun Jung Kwon, Min Soo Kang, Jung Hoon Choi, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang   +10 more
doaj   +1 more source

Synchronous activity patterns in the dentate gyrus during immobility

eLife, 2021
The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also
Martin Pofahl, Negar Nikbakht, André N Haubrich, Theresa Nguyen, Nicola Masala, Fabian Distler, Oliver Braganza, Jakob H Macke, Laura A Ewell, Kurtulus Golcuk, Heinz Beck   +10 more
doaj   +1 more source

Early natural stimulation through environmental enrichment accelerates neuronal development in the mouse dentate gyrus. [PDF]

PLoS ONE, 2012
The dentate gyrus is the primary afferent into the hippocampal formation, with important functions in learning and memory. Granule cells, the principle neuronal type in the dentate gyrus, are mostly formed postnatally, in a process that continues into ...
Na Liu, Shan He, Xiang Yu
doaj   +1 more source

Postnatal changes in glucose transporter 3 expression in the dentate gyrus of the C57BL/6 mouse model

Laboratory Animal Research, 2016
In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28, and 56.
Hyo Young Jung, Hee Sun Yim, Dae Young Yoo, Jong Whi Kim, Jin Young Chung, Je Kyung Seong, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang   +8 more
doaj   +1 more source

In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus

Journal of Pharmacological Sciences, 2013
Edaravone is clinically used in Japan for treatment of patients with acute cerebral infarction. To clarify the effect of edaravone on neurogenesis in the hippocampus following neuronal injury in the hippocampal dentate gyrus, we investigated the effect ...
Maho Kikuta, Tatsuo Shiba, Masanori Yoneyama, Koichi Kawada, Taro Yamaguchi, Eiichi Hinoi, Yukio Yoneda, Kiyokazu Ogita   +7 more
doaj   +1 more source

Status epilepticus induced Gadd45b is required for augmented dentate neurogenesis

Stem Cell Research, 2020
In animal models with temporal lobe epilepsy (TLE), the status epilepticus (SE) leads to a dramatic increase in number of newly born neuron in the subgranular zone (SGZ) of dentate gyrus.
Xin-Li Xiao, Xiao-Lin Wu, Peng-Bo Yang, Hai-Bo Hu, Yu Chen, Min-Li, Kai-Wei Si, Feng Wu, Jian-Xin Liu   +8 more
doaj   +1 more source

Beneficial In Vivo Effect of Aripiprazole on Neuronal Regeneration Following Neuronal Loss in the Dentate Gyrus: Evaluation Using a Mouse Model of Trimethyltin-Induced Neuronal Loss/Self-Repair in the Dentate Gyrus

Journal of Pharmacological Sciences, 2014
.: Aripiprazole is used clinically as an atypical antipsychotic. We evaluated the effect of in vivo treatment with aripiprazole on the proliferation and differentiation of neural stem/progenitor cells in a mouse model, trimethyltin-induced neuronal loss ...
Masanori Yoneyama, Shigeru Hasebe, Noriko Kawamoto, Tatsuo Shiba, Taro Yamaguchi, Maho Kikuta, Makoto Shuto, Kiyokazu Ogita   +7 more
doaj   +1 more source