Results 121 to 130 of about 63,053 (291)
Aging Cell, EarlyView.In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu +8 more
wiley +1 more source
Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice [PDF]
, 1997 Stéphane Schurmans +9 more
openalex +1 more source
Aging Cell, EarlyView.DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima +8 more
wiley +1 more source
The ethanol metabolite acetaldehyde inhibits the induction of long‐term potentiation in the rat dentate gyrus in vivo [PDF]
, 1999 Kazuho Abe +3 more
openalex +1 more source
Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
British Journal of Pharmacology, EarlyView.Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota +4 more
wiley +1 more source
Highly Specific Neuron Loss Preserves Lateral Inhibitory Circuits in the Dentate Gyrus of Kainate-Induced Epileptic Rats [PDF]
, 1999 Paul S. Buckmaster +1 more
openalex +1 more source
Cell Proliferation, EarlyView.Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao +15 more
wiley +1 more source
Preferential superficial cortical layer activation during seizure propagation
Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya +4 more
wiley +1 more source
Unique Expression Patterns of Cell Fate Molecules Delineate Sequential Stages of Dentate Gyrus Development [PDF]
, 2000 Samuel J. Pleasure +2 more
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Fast activity chirp patterns in focal seizures from patients and animal models
Epilepsia, Volume 66, Issue 3, Page 621-631, March 2025.Abstract Time–frequency analysis of focal seizure electroencephalographic signals performed with depth electrodes in human temporal lobe structures has revealed the occurrence at onset of oscillations at approximately 30–100 Hz that feature a monotonic rapid decay in frequency content.
Maxime Lévesque +6 more
wiley +1 more source