Results 171 to 180 of about 116,345 (333)
Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area [PDF]
Siavash Ahmadi +5 more
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Brain Pathology, EarlyView.x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz +9 more
wiley +1 more source
Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity
Brain Pathology, EarlyView.Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen +12 more
wiley +1 more source
Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy
Neurobiology of DiseaseGain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ...
Wenxi Yu +6 more
doaj +1 more source
Brain Pathology, EarlyView.We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata +2 more
wiley +1 more source
Ectopic Granule Cells of the Rat Dentate Gyrus [PDF]
, 2006 Helen E. Scharfman +2 more
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Brain Pathology, EarlyView.The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown +7 more
wiley +1 more source
Depotentiation in the Dentate Gyrus of Freely Moving Rats is Modulated by D1/D5 Dopamine Receptors [PDF]
, 2000 Alexander Kulla
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