Results 171 to 180 of about 63,053 (291)

Targeting necroptosis protects against astrocyte death and hippocampal sclerosis in experimental temporal lobe epilepsy

The Journal of Physiology, EarlyView.
Abstract figure legend Experimentally induced status epilepticus induces microglial TNFα release, which binds to astrocytic TNFR1 and triggers activation of RIPK1/RIPK3/MLKL signalling, initiating necroptotic astrocytic death that contributes to the development of hippocampal sclerosis. Created with Biorender.com.
Zhou Wu, Lukas Henning, Christian Steinhäuser, Peter Bedner   +3 more
wiley   +1 more source

Lifetime Variations of Prolactin Receptor Isoforms mRNA in the Hippocampus and Dentate Gyrus of the Rat-Effects of Aging. [PDF]

Int J Mol Sci
Carretero-Hernández M, Herráez E, Hernández-González D, Díez-Castro D, Catalano-Iniesta L, García-Barrado J, Blanco EJ, Carretero J.   +7 more
europepmc   +1 more source

Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development

, 2000
J. R. O'Kusky, P. Ye, A. J. D'Ercole
openalex   +2 more sources

Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis [PDF]

, 2002
Helen E. Scharfman
openalex   +1 more source

The dentate gyrus in depression: directions for future research [PDF]

Molecular Psychiatry, 2020
Iris E. C. Sommer, René C.W. Mandl, Jasper O. Nuninga, Jasper O. Nuninga   +3 more
openaire   +3 more sources

Spatial transcriptomics iterative hierarchical clustering (stIHC): A novel method for identifying spatial gene co‐expression modules

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Recent advancements in spatial transcriptomics (ST) technologies allow researchers to simultaneously measure RNA expression levels for hundreds to thousands of genes while preserving spatial information within tissues, providing critical insights into spatial gene expression patterns, tissue organization, and gene functionality.
Catherine Higgins, Jingyi Jessica Li, Michelle Carey   +2 more
wiley   +1 more source

Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice. [PDF]

Nat Commun
Yuan M, Cazala A, Goedeke S, Leibold C, Sauer JF, Bartos M.   +5 more
europepmc   +1 more source

Tenascin‐R aggravates Aβ production in the perforant pathway by regulating Nav1.6 activity in APP/PS1 mice

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) neuropathology exhibits early accumulation of amyloid beta (Aβ) plaques within the perforant pathway. This study explores how tenascin‐R, a myelin‐associated protein at nodes of Ranvier (NORs), modulates Aβ generation through Nav1.6 within this cortico‐hippocampal circuit.
Bin Wang, Zhi‐Xue Wang, Lang‐Man Lv, Xi Wang, Jin‐Cheng Lu, Yi‐Fan Zhao, Rong Jiang, Qi‐fa Li, Yue Kong, Xue‐Wei Yang, Jie Luo, Zhi‐Cheng Xiao, Ai‐ping Li, Guang Yang, Quan‐Hong Ma, Li Shao   +15 more
wiley   +1 more source

Recurrent Interneuron Connectivity Does Not Support Synchrony in a Biophysical Dentate Gyrus Model. [PDF]

eNeuro
Müller-Komorowska D, Fujishige T, Fukai T.   +2 more
europepmc   +1 more source

Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection

BioEssays, Volume 47, Issue 9, September 2025.
Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley   +1 more source