MGluR5 mediates the interaction between late-LTP, network activity, and learning. [PDF]
PLoS ONE, 2008 Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena.
Arthur Bikbaev +5 more
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Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat. [PDF]
PLoS ONE, 2011 The dentate gyrus is a site of continued neurogenesis in the adult brain. The CA3 region of the hippocampus is the major projection area from the dentate gyrus. CA3 sends reciprocal projections back to the dentate gyrus.
Jian Xin Liu +2 more
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Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. [PDF]
PLoS ONE, 2009 Physical exercise has been shown to increase adult neurogenesis in the dentate gyrus and enhances synaptic plasticity. The antiapoptotic kinase, Akt has also been shown to be phosphorylated following voluntary exercise; however, it remains unknown ...
Elodie Bruel-Jungerman +5 more
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Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2 [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Prostaglandin E2 E-prostanoid 2 receptor (PGE2 EP2), downstream of cyclooxygenase-2 (COX-2), plays an important role in inflammatory responses, but there are some reports about synaptic functions of COX-2 and PGE2 EP2 in the hippocampus ...
Hyo Young Jung +10 more
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Synchronous activity patterns in the dentate gyrus during immobility
eLife, 2021 The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also
Martin Pofahl +10 more
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Early natural stimulation through environmental enrichment accelerates neuronal development in the mouse dentate gyrus. [PDF]
PLoS ONE, 2012 The dentate gyrus is the primary afferent into the hippocampal formation, with important functions in learning and memory. Granule cells, the principle neuronal type in the dentate gyrus, are mostly formed postnatally, in a process that continues into ...
Na Liu, Shan He, Xiang Yu
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Laboratory Animal Research, 2016 In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28, and 56.
Hyo Young Jung +8 more
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Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Cell & Bioscience, 2019 Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu +8 more
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Laboratory Animal Research, 2018 In the present study, we compared the cell-specific expression and changes protein levels in the glucose transporters (GLUTs) 1 and 3, the major GLUTs in the mouse and gerbil brains using immuno-histochemistry and Western blot analysis. In both mouse and
Kwon Young Lee +10 more
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Temporal changes in prosaposin expression in the rat dentate gyrus after birth. [PDF]
PLoS ONE, 2014 Neurogenesis in the hippocampal dentate gyrus occurs constitutively throughout postnatal life. Adult neurogenesis includes a multistep process that ends with the formation of a postmitotic and functionally integrated new neuron. During adult neurogenesis,
Midori Morishita +7 more
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