Results 11 to 20 of about 117,269 (356)

Enigmas of the Dentate Gyrus [PDF]

Neuron, 2007
We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate differentiation between environments ...
Leutgeb, Jill K., Moser, Edvard I.
openaire   +2 more sources

Postnatal changes in glucose transporter 3 expression in the dentate gyrus of the C57BL/6 mouse model

Laboratory Animal Research, 2016
In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28, and 56.
Hyo Young Jung, Hee Sun Yim, Dae Young Yoo, Jong Whi Kim, Jin Young Chung, Je Kyung Seong, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang   +8 more
doaj   +1 more source

In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus

Journal of Pharmacological Sciences, 2013
Edaravone is clinically used in Japan for treatment of patients with acute cerebral infarction. To clarify the effect of edaravone on neurogenesis in the hippocampus following neuronal injury in the hippocampal dentate gyrus, we investigated the effect ...
Maho Kikuta, Tatsuo Shiba, Masanori Yoneyama, Koichi Kawada, Taro Yamaguchi, Eiichi Hinoi, Yukio Yoneda, Kiyokazu Ogita   +7 more
doaj   +1 more source

Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

Cell & Bioscience, 2019
Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +8 more
doaj   +1 more source

Status epilepticus induced Gadd45b is required for augmented dentate neurogenesis

Stem Cell Research, 2020
In animal models with temporal lobe epilepsy (TLE), the status epilepticus (SE) leads to a dramatic increase in number of newly born neuron in the subgranular zone (SGZ) of dentate gyrus.
Xin-Li Xiao, Xiao-Lin Wu, Peng-Bo Yang, Hai-Bo Hu, Yu Chen, Min-Li, Kai-Wei Si, Feng Wu, Jian-Xin Liu   +8 more
doaj   +1 more source

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies) [PDF]

, 2007
The dentate gyrus is a simple cortical region that is an integral portion of the larger functional brain system called the hippocampal formation. In this review, the fundamental neuroanatomical organization of the dentate gyrus is described, including principal cell types and their connectivity, and a summary of the major extrinsic inputs of the ...
Amaral David G, Scharfman Helen E, Lavenex Pierre   +2 more
openaire   +3 more sources

Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures [PDF]

, 2012
During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation.
Becker, Denise, Deller, Thomas, Jedlicka, Peter, Maggio, Nicola, Schuldt, Gerlind, Vlachos, Andreas, Vnencak, Matej, Willems, Laurent Maximilian, Zahn, Nadine   +8 more
core   +6 more sources

Beneficial In Vivo Effect of Aripiprazole on Neuronal Regeneration Following Neuronal Loss in the Dentate Gyrus: Evaluation Using a Mouse Model of Trimethyltin-Induced Neuronal Loss/Self-Repair in the Dentate Gyrus

Journal of Pharmacological Sciences, 2014
.: Aripiprazole is used clinically as an atypical antipsychotic. We evaluated the effect of in vivo treatment with aripiprazole on the proliferation and differentiation of neural stem/progenitor cells in a mouse model, trimethyltin-induced neuronal loss ...
Masanori Yoneyama, Shigeru Hasebe, Noriko Kawamoto, Tatsuo Shiba, Taro Yamaguchi, Maho Kikuta, Makoto Shuto, Kiyokazu Ogita   +7 more
doaj   +1 more source

Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]

PLoS Computational Biology, 2014
Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada, Norberto Garcia-Cairasco, Antonio C Roque   +2 more
doaj   +1 more source

TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]

, 1997
Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad, Barbacid, Mariano, Frisén, Jonás, Río Fernández, José Antonio del, Silos-Santiago, Inmaculada, Soriano García, Eduardo   +5 more
core   +1 more source