Results 41 to 50 of about 139,984 (307)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Expression of the AMPA receptor subunits GluR1 and GluR2 is associated with granule cell maturation in the dentate gyrus

Frontiers in Neuroscience, 2011
The dentate gyrus produces new granule neurons throughout adulthood in mammals from rodents to humans. During granule cell maturation, defined markers are expressed in a highly regulated sequential process, which is necessary for directed neuronal ...
Hideo eHagihara, Hideo eHagihara, Koji eOhira, Koji eOhira, Keiko eToyama, Keiko eToyama, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa   +9 more
doaj   +1 more source

Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

eLife, 2023
Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, little is known ...
Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn DR Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yin   +6 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Computational Pattern Separation Models of Dentate Gyrus Neural Subpopulation in the Hippocampus

Caspian Journal of Neurological Sciences, 2022
Hippocampus is a part of the brain that has an essential role in memory and learning. It is involved in many cognitive and behavioral phenomena, including the pattern separation process: the ability to distinguish patterns with very high similarity.
Nazal Modhej, Azam Bastanfard, Mohammad Teshnehlab, Somayeh Raiesdana   +3 more
doaj  

Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. [PDF]

PLoS ONE, 2012
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis.
Yvonne Imielski, Jens C Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt   +12 more
doaj   +1 more source

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Activation of hypoactive parvalbumin-positive fast-spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Neurobiology of Disease
Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits.
Sang-Hun Lee, Young-Jin Kang, Bret N. Smith   +2 more
doaj   +1 more source

Neurogenesis in the dentate gyrus: carrying the message or dictating the tone

Frontiers in Neuroscience, 2013
The dentate gyrus is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas.
Verónica C Piatti, Laura A. Ewell, Jill K. Leutgeb   +2 more
doaj   +1 more source