Results 51 to 60 of about 117,269 (356)

Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks. [PDF]

, 2013
The brain is able to construct internal representations that correspond to external spatial coordinates. Such brain maps of the external spatial topography may support a number of cognitive functions, including navigation and memory.
Brandon, Mark P, Koenig, Julie, Leutgeb, Stefan   +2 more
core   +2 more sources

Sex steroids and the dentate gyrus [PDF]

, 2007
In the late 1980s, the finding that the dentate gyrus contains more granule cells in the male than in the female of certain mouse strains provided the first indication that the dentate gyrus is a significant target for the effects of sex steroids during development. Gonadal hormones also play a crucial role in shaping the function and morphology of the
Tibor, Hajszan, Teresa A, Milner, Csaba, Leranth   +2 more
openaire   +2 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis

Frontiers in Molecular Neuroscience, 2023
Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseased brains. The tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome 10 (Pten) has previously been found to ...
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo   +4 more
doaj   +1 more source

Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response [PDF]

, 2011
The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works.
Azami, N.S., Heidari, M., Jahanshahi, M., Khoshnazar, A.K.   +3 more
core  

The similarity of astrocytes number in dentate gyrus and CA3 subfield of rats hippocampus [PDF]

, 2007
The dentate gyrus is a part of hippocampal formation that it contains granule cells, which project to the pyramidal cells and interneurons of the CA3 subfield of the hippocampus.
Hosseini, A., Jahanshahi, M., Naghdi, N., Sadeghi, Y.   +3 more
core   +1 more source

Nonrandom Local Circuits in the Dentate Gyrus [PDF]

The Journal of Neuroscience, 2008
The dentate hilus has been extensively studied in relation to its potential role in memory and in temporal lobe epilepsy. Little is known, however, about the synapses formed between the two major cell types in this region, glutamatergic mossy cells and hilar interneurons, or the organization of local circuits involving these cells.
Phillip, Larimer, Ben W, Strowbridge
openaire   +2 more sources

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Activation of hypoactive parvalbumin-positive fast-spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Neurobiology of Disease
Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits.
Sang-Hun Lee, Young-Jin Kang, Bret N. Smith   +2 more
doaj   +1 more source

Neurogenesis in the dentate gyrus: carrying the message or dictating the tone

Frontiers in Neuroscience, 2013
The dentate gyrus is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas.
Verónica C Piatti, Laura A. Ewell, Jill K. Leutgeb   +2 more
doaj   +1 more source