Results 11 to 20 of about 54,854 (258)
Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant. [PDF]
Comput Struct Biotechnol J5-Hydroxymethyl-2′-deoxycytidine (5hmdC) is an important epigenetic marker involved in gene regulation and DNA demethylation. It has potential use as a biomarker for cancer and other diseases due to its significant depletion in various cancers and ...
Sahin H +7 more
europepmc +3 more sources
Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis
Frontiers in Plant Science, 2021 CTP synthases (CTPS) comprise a protein family of the five members CTPS1-CTPS5 in Arabidopsis, all located in the cytosol. Specifically, downregulation of CTPS2 by amiRNA technology results in plants with defects in chlorophyll accumulation and ...
Leo Bellin +7 more
doaj +1 more source
Activity of combined gemcitabine therapy on treatment of planocellular carcinoma: A pilot study [PDF]
Archive of Oncology, 2004 BACKGROUND: Drug-orientated, pilot study was conducted to estimate the activity of gemcitabine on treatment of head and neck and lung planocellular carcinoma in combination with either radiotherapy or chemotherapy.
Šćepanović Danijela S. +2 more
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Pathogens, 2023 Background: Chronic hepatitis B virus (HBV) infection is a common chronic liver disease that is closely associated with increased morbidity and mortality. Circulating cell-free DNA (cf-DNA) and global DNA methylation, expressed as circulating levels of 5-
Nikolaos D. Karakousis +7 more
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Neural Regeneration Research, 2023 Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and ...
Guang Shi +3 more
doaj +1 more source
Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity. [PDF]
PLoS ONE, 2009 Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not ...
Christopher A Hamm +10 more
doaj +1 more source
Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2'-deoxycytidine level in cultured cancerous cell lines. [PDF]
PLoS ONE, 2017 Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed by enzymes of the Ten-Eleven Translocation family proteins (TETs 1, 2 and 3).
Marek Foksinski +12 more
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Scientific Reports, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová +3 more
doaj +1 more source
Separations, 2021 Artemisinin (ART) is a sesquiterpene lactone and a popular malaria drug with potential anticancer properties. In this work, LC/TOF/MS, was used to investigate the reaction of ART with DNA bases. ART-deoxyadenosine and ART-deoxycytidine interactions, were
Kogila Oke, Amos Mugweru
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DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer
Technology in Cancer Research & Treatment, 2020 Background: The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer.
Shu Fang Hu MM +5 more
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