Results 231 to 240 of about 54,854 (258)
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Electron Attachment to Microhydrated Deoxycytidine Monophosphate
The Journal of Physical Chemistry B, 2018DNA constituents are effectively decomposed via dissociative electron attachment (DEA). However, the DEA contribution to radiation damage in living tissues is a subject of ongoing discussion. We address an essential question, how aqueous environment influences the DEA to DNA.
Jaroslav Kočišek +4 more
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Regulation of human deoxycytidine kinase expression
Advances in Enzyme Regulation, 1993The human deoxycytidine kinase gene is a single copy gene and is comprised of seven exons that are spread over more than 34 kb of the genome. The 5'-flanking region is highly G/C rich and does not contain CAAT or TATA boxes. This region, when cloned into a recorder gene construct containing the chloramphenicol acetyltransferase gene, is capable of ...
B S, Mitchell +4 more
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5'-Substituted 2'-Deoxycytidines as Non-Substrate Inhibitors of Human Deoxycytidine Kinase
Nucleosides, Nucleotides and Nucleic Acids, 1995Abstract Several 5′-substituted analogues of 2′-deoxycytidine (dC), including 5′-amino2′,5′-dideoxycytidine (5′-amino-ddC), 5′-azido-2′,5′-dideoxycytidine (5′-azido-ddC) and 5′-O-ethyl-2′-deoxycytidine (5′-O-ethyl-dC), are non-substrate inhibitors of human dC kinase.
K. Krawiec, B. Kierdaszuk, D. Shugar
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5-Ethyl-2'-deoxycytidine, C11H17N3O4
Acta Crystallographica Section C Crystal Structure Communications, 1995The deoxyribose ring in the title compound adopts the twist conformation ( 3 2 T) with a glycosyl torsion angle of 231.0 (6)°. The pseudo-rotation parameters are P = 180.29 (5)° and τ m = 38.3 (5)°. The exocyclic side chain at C5' has the t conformation [γ = 174.8(11)°].
S. Napper +4 more
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Theoretical analysis of deoxycytidine‐5′‐phosphate protonation
Biopolymers, 1990AbstractThe electron density distribution in deoxycytidine‐5′‐monophosphate (5′‐dCMP) molecule and dianion has been studied by the method of CNDO/2. The comparison between the results of calculation for the neutral molecule and the data obtained by Pearlman and Kim13 shows that there is a linear correlation between the atomic charges calculated using ...
E B, Starikov, Y F, Pedash
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Biochemical Pharmacology, 2003
Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.
Gergely, Keszler +5 more
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Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.
Gergely, Keszler +5 more
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Structure of 5-methyl-2'-deoxycytidine
Acta Crystallographica Section C Crystal Structure Communications, 1988C10H15N3O4, Mr = 241.2, orthorhombic, P2(1)2(1)2(1), a = 10.454 (1), b = 11.922 (1), c = 9.057 (1) A, V = 1128.9 (1) A3, Z = 4, D chi = 1.419 Mg m-3, Cu K alpha radiation, lambda = 1.54178 A, mu = 0.95 mm-1, F(000) = 512, room temperature, R = 0.029 for 1186 observed reflections.
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Phosphorylation of 5-Halogenated Deoxycytidine Analogues by Deoxycytidine Kinase
Molecular Pharmacology, 1973G M, Cooper, S, Greer
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Deoxycytidine: a morphine antagonist.
Archives internationales de pharmacodynamie et de therapie, 1978Deoxycytidine antagonizes the analgesic action of morphine in the rat, morphine-induced respiratory depression in the rabbit and mitigates withdrawal in the dependent mouse. Administration of deoxycytidine does not precipitate the abstinence syndrome in dependent mice, a property shared by certain other endogenous morphine antagonsits.
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