Results 31 to 40 of about 25,107 (224)
Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]
, 2019 Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F. +4 more
core +1 more source
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
Nature Communications, 2017 Masitinib is a protein kinase inhibitor that sensitises refractory pancreatic adenocarcinoma cells to treatment with the nucleoside analog gemcitabine.
Kahina Hammam +18 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is ...
Evan R. Abt +24 more
doaj +1 more source
Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer. [PDF]
, 2014 BackgroundPancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to overcome this chemo-resistance have ...
Bold, Richard J +3 more
core +2 more sources
Ecotoxicology and Environmental Safety, 2021 Plants as sessile organisms have developed some unique strategies to withstand environmental stress and adaptive response (AR) is one of them. In the present study Cadmium (Cd)-induced AR was evaluated to ameliorate the genotoxicity of a known chemical ...
Manoswini Chakrabarti, Anita Mukherjee
doaj +1 more source
PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2022 Background and objectives: The occurrence and development of lung cancer are closely linked to epigenetic modification. Abnormal DNA methylation in the CpG island region of genes has been found in many cancers.
Jing LI +8 more
doaj +1 more source
Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging
Neural Regeneration Research, 2021 Acupuncture can reduce cognitive deficits in Alzheimer’s disease. However, whether electroacupuncture can prevent or alleviate the cognitive deficits in animal models of aging remains poorly understood.
Chao-Chao Yu +10 more
doaj +1 more source
A general method for purification of deoxycytidine kinase [PDF]
Biochemical Journal, 1978 Deoxycytidine kinase from a variety of animal tissues binds to Cibacron Blue 3G-A coupled to Sepharose CL-6B. The enzyme can be selectively eluted with ATP to yield single-step purifications of 17-89-fold. The affinity adsorbent is re-usable.
A, Baxter, L M, Currie, J P, Durham
openaire +2 more sources
Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting [PDF]
, 2015 Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (
Alsop, Amber +12 more
core +1 more source
mSphere, 2019 Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes +6 more
doaj +1 more source